GBP1

Description		guanylate binding protein 1
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Vesicle Membrane Actin Cytoskeleton Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Symbiont Cell Surface
	Molecular Function	Nucleotide Binding Lipopolysaccharide Binding Actin Binding GTPase Activity G Protein Activity GDP Phosphatase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Enzyme Binding Cytokine Binding Spectrin Binding Identical Protein Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Immune System Process Negative Regulation Of Interleukin-2 Production Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Regulation Of Calcium-mediated Signaling Negative Regulation Of T Cell Receptor Signaling Pathway Protein Maturation Defense Response To Virus Cytolysis In Another Organism Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Protein Localization To Vacuole Positive Regulation Of Pyroptotic Inflammatory Response Non-canonical Inflammasome Complex Assembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Interferon gamma signaling CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity
Drugs
Diseases
GWAS		Remission after SSRI treatment in MDD or openness ( 29559929) Serum metabolite levels ( 33031748)
Novel Interacting Genes		1 novel interacting genes: PTBP2
Interacting Genes		2 interacting genes: FNTA FNTB
Entrez ID		2633
HPRD ID		02681
Ensembl ID		ENSG00000117228
Uniprot IDs		P32455
PDB IDs		1DG3 1F5N 2B8W 2B92 2BC9 2D4H 6K1Z 6K2D 6LOJ 8CQB 8Q4L 8R1A
Enriched GO Terms of Interacting Partners?		Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Protein Farnesylation Protein Prenyltransferase Activity Protein Prenylation Prenyltransferase Activity Acetyltransferase Activator Activity Microtubule Associated Complex Regulation Of Microtubule-based Movement Peptide Pheromone Maturation CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Regulation Of Microtubule-based Process Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Protein Geranylgeranylation Enzyme Binding Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Nuclear Envelope Organization Negative Regulation Of RNA Splicing Peptide Binding Spinal Cord Development Regulation Of Rac Protein Signal Transduction MRNA Splice Site Recognition Neuromuscular Junction Development Alpha-tubulin Binding Receptor Clustering Cerebellum Development Receptor Tyrosine Kinase Binding Positive Regulation Of Small GTPase Mediated Signal Transduction
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