SLITRK1

Description		SLIT and NTRK like family member 1
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Synapse Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding
	Biological Process	Endocytosis Nervous System Development Axonogenesis Synapse Assembly Gene Expression Adult Behavior Multicellular Organism Growth Norepinephrine Metabolic Process Homeostatic Process Positive Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Vocalization Behavior Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Neuron Projection Extension
Pathways		Receptor-type tyrosine-protein phosphatases
Drugs
Diseases		Tourette syndrome Trichotillomania
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder (mania) ( 23326512) Carotid intima media thickness x smoking interaction ( 32117412) Cerebral amyloid deposition (PET imaging) ( 30361487) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Hepcidin/transferrin saturation ratio ( 27846281) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Squamous cell lung carcinoma ( 28604730) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		3 interacting genes: PTPRD PTPRS UBQLN2
Entrez ID		114798
HPRD ID		18063
Ensembl ID		ENSG00000178235
Uniprot IDs		Q96PX8
PDB IDs		4RCA 4RCW
Enriched GO Terms of Interacting Partners?		Regulation Of Postsynaptic Specialization Assembly Regulation Of Postsynaptic Density Assembly Regulation Of Organelle Assembly Regulation Of Excitatory Synapse Assembly Synaptic Membrane Adhesion Regulation Of Dendritic Spine Development Schaffer Collateral - CA1 Synapse Protein Tyrosine Phosphatase Activity Regulation Of Postsynapse Organization Presynaptic Membrane Phosphoprotein Phosphatase Activity Regulation Of Synapse Assembly Regulation Of Organelle Organization Negative Regulation Of G Protein-coupled Receptor Internalization Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cell Junction Assembly Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Interferon-alpha Production Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Synapse Organization Trans-synaptic Signaling By Trans-synaptic Complex Trans-synaptic Signaling Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Synaptic Signaling Regulation Of Neurogenesis Presynaptic Membrane Assembly Negative Regulation Of Dendritic Spine Development Presynaptic Membrane Organization Chondroitin Sulfate Binding Regulation Of Neuron Projection Development Regulation Of Nervous System Development Regulation Of Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Presynapse Assembly Negative Regulation Of Neuron Projection Regeneration Cell-cell Adhesion Modulation Of Chemical Synaptic Transmission Establishment Of Endothelial Intestinal Barrier Negative Regulation Of Interferon-beta Production Regulation Of Cellular Component Organization Transmembrane Receptor Protein Tyrosine Phosphatase Activity Presynapse Organization Glutamatergic Synapse Positive Regulation Of Dendritic Spine Morphogenesis Corpus Callosum Development Regulation Of Cellular Response To Stress Heparan Sulfate Proteoglycan Binding Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization
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