MACROH2A1 and TRIM59

Number of citations of the paper that reports this interaction (PubMedID 31488827)
65

Data Source:
BioGRID (enzymatic study)

		MACROH2A1	TRIM59
Description		macroH2A.1 histone	tripartite motif containing 59
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleosome Condensed Chromosome Sex Chromatin Barr Body Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Extracellular Exosome Site Of DNA Damage	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intraciliary Transport Particle B
	Molecular Function	RDNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding Double-stranded Methylated DNA Binding Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity ADP-D-ribose Binding ADP-D-ribose Modification-dependent Protein Binding Poly-ADP-D-ribose Modification-dependent Protein Binding Promoter-specific Chromatin Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Oxidative Phosphorylation DNA Repair Chromatin Organization Nucleosome Assembly Dosage Compensation By Inactivation Of X Chromosome Regulation Of Lipid Metabolic Process Heterochromatin Formation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Epigenetic Regulation Of Gene Expression Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling Regulation Of RDNA Heterochromatin Formation Protein Poly-ADP-ribosylation Establishment Of Protein Localization To Chromatin Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of NAD Metabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Response To Oxidative Stress Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Response To Oxidative Stress Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Protein Localization To Chromosome, Telomeric Region	Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Host-mediated Suppression Of Symbiont Invasion
Pathways
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		21 interacting genes: APP ATF2 ATXN1L BARD1 BRCA1 CYSRT1 ERICH2 FAM133A H2BC15 KRTAP10-8 NKAPD1 PARP1 RNF168 SPOP SREK1IP1 SRPK1 TRAF2 TRIM26 TRIM59 VCX2 ZNF622	29 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KEAP1 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PKNOX1 PLLP RASSF3 RHOU SEC22A SNAP47 SYVN1 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22
Entrez ID		9555	286827
HPRD ID		13624	15568
Ensembl ID		ENSG00000113648	ENSG00000213186
Uniprot IDs		A0A994J4J7 B4DJC3 O75367	Q8IWR1
PDB IDs		1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB 5IIT 5LNC 7D3Y
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Protein Polyubiquitination Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Chromatin Organization Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification Process Chromatin Remodeling Ubiquitin Ligase Complex BRCA1-B Complex Protein Modification By Small Protein Conjugation Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Response To Ionizing Radiation Zinc Ion Binding BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Intrinsic Apoptotic Signaling Pathway Innate Immune Response Identical Protein Binding Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of RNA Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair DNA Recombination Protein Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Site Of Double-strand Break Chromatin Binding Ubiquitin-protein Transferase Activity DNA Damage Checkpoint Signaling Response To Other Organism Negative Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Cell Cycle Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA Damage Checkpoint Host-mediated Suppression Of Symbiont Invasion Regulation Of Cellular Response To Stress DNA Repair-dependent Chromatin Remodeling Ubiquitin Protein Ligase Binding Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Programmed Cell Death Protein K6-linked Ubiquitination Regulation Of Phosphorus Metabolic Process	Nuclear Estrogen Receptor Activity SNAP Receptor Activity Negative Regulation Of Response To Oxidative Stress
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