H2AFY and ERICH2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		H2AFY	ERICH2
Gene Name		H2A histone family, member Y	glutamate-rich 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nuclear Chromatin Condensed Chromosome Sex Chromatin Barr Body Nucleus Nucleoplasm Pericentric Heterochromatin Nucleolus ESC/E(Z) Complex Extracellular Vesicular Exosome
	Molecular Function	RDNA Binding DNA Binding Protein Binding Double-stranded Methylated DNA Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Chromatin DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Growth Nucleosome Assembly Dosage Compensation Chromatin Modification Negative Regulation Of Histone Phosphorylation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Chromatin Silencing At RDNA Establishment Of Protein Localization To Chromatin Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Negative Regulation Of Cell Cycle G2/M Phase Transition
Pathways
Drugs
Diseases
GWAS		AIDS progression ( 21502085) Immune response to anthrax vaccine ( 22658931) Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: APP ATF2 ATXN1L BRCA1 ERICH2 PARP1 SPOP SRPK1	3 interactors: H2AFY IWS1 SDCBP
Entrez ID		9555	285141
HPRD ID		13624
Ensembl ID		ENSG00000113648
Uniprot IDs		B4DJC3 O75367
PDB IDs		1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB
Enriched GO Terms of Interacting Partners?		Cellular Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transforming Growth Factor Beta2 Production Synaptic Growth At Neuromuscular Junction Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Double-strand Break Repair Protein Poly-ADP-ribosylation Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Collateral Sprouting In Absence Of Injury Regulation Of Growth Rate Positive Regulation Of Hematopoietic Stem Cell Proliferation Developmental Process DNA Damage Checkpoint Nitrogen Compound Metabolic Process Protein Metabolic Process Response To Stress Gene Expression Innate Immune Response Cellular Response To DNA Damage Stimulus Cellular Response To Indole-3-methanol Collateral Sprouting Axon Midline Choice Point Recognition Intracellular Receptor Signaling Pathway Negative Regulation Of Centriole Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Chromosome Segregation Immune System Process	Regulation Of Organelle Organization Regulation Of Histone Modification Regulation Of Histone H3-K36 Trimethylation Regulation Of Chromosome Organization Negative Regulation Of Histone Phosphorylation Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Cellular Component Organization Regulation Of Extracellular Vesicular Exosome Assembly Establishment Of Protein Localization To Chromatin Regulation Of MRNA Export From Nucleus Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension Protein Localization To Chromatin Dosage Compensation Regulation Of RNA Export From Nucleus Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Histone H4 Acetylation Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Organelle Assembly Protein Localization To Chromosome Substrate-dependent Cell Migration Regulation Of Cellular Localization Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Histone Acetylation Regulation Of Histone Methylation Positive Regulation Of Exocytosis
Tagcloud ?		2a1 activate chromatin conserved diminished driving eis enrichment erbb2 evolutionarily hypothesized immunoprecipitation insertion interact interacted interaction isoforms macro macrohistone mh2a1 nuclei overexpress overexpression stably sufficient transcription transfected trinucleotide tumorigenicity
Tagcloud (Difference) ?		2a1 activate chromatin conserved diminished driving eis enrichment erbb2 evolutionarily hypothesized immunoprecipitation insertion interact interacted interaction isoforms macro macrohistone mh2a1 nuclei overexpress overexpression stably sufficient transcription transfected trinucleotide tumorigenicity
Tagcloud (Intersection) ?