MACROH2A1 and ZNF622

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MACROH2A1	ZNF622
Description		macroH2A.1 histone	zinc finger protein 622
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleosome Condensed Chromosome Sex Chromatin Barr Body Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Extracellular Exosome Site Of DNA Damage	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Preribosome, Large Subunit Precursor
	Molecular Function	RDNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding Double-stranded Methylated DNA Binding Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity ADP-D-ribose Binding ADP-D-ribose Modification-dependent Protein Binding Poly-ADP-D-ribose Modification-dependent Protein Binding Promoter-specific Chromatin Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Preribosome Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Oxidative Phosphorylation DNA Repair Chromatin Organization Nucleosome Assembly Dosage Compensation By Inactivation Of X Chromosome Regulation Of Lipid Metabolic Process Heterochromatin Formation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Epigenetic Regulation Of Gene Expression Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling Regulation Of RDNA Heterochromatin Formation Protein Poly-ADP-ribosylation Establishment Of Protein Localization To Chromatin Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of NAD Metabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Response To Oxidative Stress Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Response To Oxidative Stress Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Protein Localization To Chromosome, Telomeric Region	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Kinase Activity Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade
Pathways
Drugs
Diseases
GWAS			Attention function in attention deficit hyperactive disorder ( 26174813)
Interacting Genes		21 interacting genes: APP ATF2 ATXN1L BARD1 BRCA1 CYSRT1 ERICH2 FAM133A H2BC15 KRTAP10-8 NKAPD1 PARP1 RNF168 SPOP SREK1IP1 SRPK1 TRAF2 TRIM26 TRIM59 VCX2 ZNF622	9 interacting genes: APP BEND7 CDC42 HMGB2 MACROH2A1 MELK MYBL2 OGT PRKN
Entrez ID		9555	90441
HPRD ID		13624	12278
Ensembl ID		ENSG00000113648	ENSG00000173545
Uniprot IDs		A0A994J4J7 B4DJC3 O75367	Q969S3
PDB IDs		1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB 5IIT 5LNC 7D3Y	6LQM 6LSR 9GMO
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Protein Polyubiquitination Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Chromatin Organization Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification Process Chromatin Remodeling Ubiquitin Ligase Complex BRCA1-B Complex Protein Modification By Small Protein Conjugation Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Response To Ionizing Radiation Zinc Ion Binding BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Intrinsic Apoptotic Signaling Pathway Innate Immune Response Identical Protein Binding Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of RNA Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair DNA Recombination Protein Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Site Of Double-strand Break Chromatin Binding Ubiquitin-protein Transferase Activity DNA Damage Checkpoint Signaling Response To Other Organism Negative Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Cell Cycle Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA Damage Checkpoint Host-mediated Suppression Of Symbiont Invasion Regulation Of Cellular Response To Stress DNA Repair-dependent Chromatin Remodeling Ubiquitin Protein Ligase Binding Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Programmed Cell Death Protein K6-linked Ubiquitination Regulation Of Phosphorus Metabolic Process	Regulation Of Purine Nucleotide Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Spontaneous Synaptic Transmission Regulation Of ATP Metabolic Process Cellular Response To Manganese Ion RAGE Receptor Binding Regulation Of Small Molecule Metabolic Process Protein-containing Complex Response To Manganese Ion Cellular Component Assembly Cellular Response To Catecholamine Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Neurotransmitter Uptake Response To Catecholamine Negative Regulation Of Transcription By RNA Polymerase II Hemopoiesis Amyloid Fibril Formation Regulation Of Response To Oxidative Stress Positive Regulation Of Proteolysis Regulation Of Phosphorus Metabolic Process Negative Regulation Of Gene Expression Chemoattractant Activity Regulation Of Necroptotic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Metabolic Process Negative Regulation Of Protein Localization Condensed Chromosome Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Gene Expression Postsynapse Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Neuron Projection Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Chemotaxis Positive Regulation Of Developmental Process Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Gene Expression, Epigenetic Protein-containing Complex Organization Regulation Of Glycolytic Process Negative Regulation Of RNA Metabolic Process Mitophagy Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Regulation Of Transcription By RNA Polymerase II
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