MSH6

Name	mutS homolog 6
Structure
Novel Interactors	2 novel interactors: BBS7 XPO1
Interactors	20 interactors: BARD1 BRCA1 CEBPA CHAF1A CREBBP CSNK2A1 EP300 HRAS HUS1 MAP2K1 MSH2 MUTYH NANS PCNA PTEN RAD1 RAD9A SMC1A SUMO2 WEE2-AS1
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Golgi Apparatus Cytosol MutSalpha Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Four-way Junction DNA Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding Histone H3K36me3 Reader Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	Meiotic Mismatch Repair DNA Repair Mismatch Repair Chromatin Organization DNA Damage Response Spermatogenesis Determination Of Adult Lifespan Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Intrinsic Apoptotic Signaling Pathway
Pathways	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6
Diseases	Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Colorectal cancer
GWAS	General risk tolerance (MTAG) ( 30643258 ) Heel bone mineral density ( 30598549 ) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187 ) Menopause (age at onset) ( 26414677 ) Takayasu arteritis ( 25604533 ) Tea consumption ( 31046077 )
Entrez ID	2956
HPRD ID	07202
Ensembl ID	ENSG00000116062
Uniprot IDs	A0A494C0M1 A0A8V8TPJ4 P52701 Q3SWU9
PDB IDs	2GFU 2O8B 2O8C 2O8D 2O8E 2O8F 6OQM 8AG6
GO Terms Enriched among Interactors ?	Cellular Response To Radiation DNA Repair DNA Damage Response Response To Radiation DNA Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Damaged DNA Binding Response To Ionizing Radiation Cellular Response To Ionizing Radiation Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Response To Stress Nucleic Acid Metabolic Process Regulation Of Cell Cycle Checkpoint Clamp Complex Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition MutLalpha Complex Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Cell Cycle Process Regulation Of Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Nucleus DNA Recombination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Transcription By RNA Polymerase II BRCA1-BARD1 Complex Chromatin Binding Response To UV Histone H3K27 Acetyltransferase Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Catabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Dinucleotide Insertion Or Deletion Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process