MSH6

Gene Name		mutS homolog 6
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Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nuclear Chromatin Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane MutSalpha Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Magnesium Ion Binding Four-way Junction DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity ATPase Activity Mismatched DNA Binding Guanine/thymine Mispair Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Methylated Histone Binding Protein Homodimerization Activity ADP Binding
	Biological Process	Meiotic Mismatch Repair DNA Repair Mismatch Repair Reciprocal Meiotic Recombination Determination Of Adult Lifespan Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity Intrinsic Apoptotic Signaling Pathway
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS
Protein-protein Interactions		13 interactors: BARD1 BRCA1 CHAF1A CREBBP CSNK2A1 EP300 HUS1 MSH2 MUTYH PCNA RAD1 RAD9A SMC1A
Entrez ID		2956
HPRD ID		07202
Ensembl ID		ENSG00000116062
Uniprot IDs		B4DF41 B4E3I4 F5H2F9 P52701 Q3SWU9
PDB IDs		2GFU 2O8B 2O8C 2O8D 2O8E 2O8F
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress Cell Cycle Cell Cycle Process DNA Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Response To Ionizing Radiation DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Response To Abiotic Stimulus Mitotic Cell Cycle Process Mitotic Cell Cycle Cellular Response To Stimulus Response To Radiation Negative Regulation Of Mitotic Cell Cycle Postreplication Repair N-terminal Peptidyl-lysine Acetylation Response To Stimulus Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Mismatch Repair Regulation Of Cell Cycle Process Cellular Response To Ionizing Radiation DNA Recombination Protein K6-linked Ubiquitination Chromosome Organization Negative Regulation Of Cell Division Intra-S DNA Damage Checkpoint Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process N-terminal Protein Amino Acid Acetylation Negative Regulation Of DNA Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Signal Transduction By P53 Class Mediator Regulation Of DNA Replication DNA Catabolic Process Cellular Response To Radiation Negative Regulation Of Meiotic Nuclear Division
Tagcloud ?		aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh mlh1 mlh3 msh5 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e