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MSH6 and CHAF1A
Number of citations of the paper that reports this interaction (PubMedID
22232658
)
34
Data Source:
BioGRID
(far western blotting, pull down, affinity chromatography technology)
MSH6
CHAF1A
Description
mutS homolog 6
chromatin assembly factor 1 subunit A
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Chromosome
Golgi Apparatus
Cytosol
MutSalpha Complex
Chromatin
Nucleus
Protein-containing Complex
CAF-1 Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
Double-stranded DNA Binding
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Enzyme Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
Single Guanine Insertion Binding
Single Thymine Insertion Binding
Oxidized Purine DNA Binding
MutLalpha Complex Binding
Protein Homodimerization Activity
ADP Binding
Histone H3K36me3 Reader Activity
ATP-dependent DNA Damage Sensor Activity
Chromatin Binding
Protein Binding
Identical Protein Binding
Unfolded Protein Binding
Chromo Shadow Domain Binding
Biological Process
Meiotic Mismatch Repair
DNA Repair
Mismatch Repair
Chromatin Organization
DNA Damage Response
Spermatogenesis
Determination Of Adult Lifespan
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
Maintenance Of DNA Repeat Elements
Isotype Switching
Negative Regulation Of DNA Recombination
Intrinsic Apoptotic Signaling Pathway
DNA Replication
DNA Repair
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Chromatin Assembly
DNA Damage Response
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH6
Drugs
Diseases
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Colorectal cancer
GWAS
General risk tolerance (MTAG) (
30643258
)
Heel bone mineral density (
30598549
)
Lifetime average cigarettes per day in chronic obstructive pulmonary disease (
21685187
)
Menopause (age at onset) (
26414677
)
Takayasu arteritis (
25604533
)
Tea consumption (
31046077
)
Hemoglobin (
32888494
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
27863252
28957414
32888494
)
Interacting Genes
20 interacting genes:
BARD1
BRCA1
CEBPA
CHAF1A
CREBBP
CSNK2A1
EP300
HRAS
HUS1
MAP2K1
MSH2
MUTYH
NANS
PCNA
PTEN
RAD1
RAD9A
SMC1A
SUMO2
WEE2-AS1
47 interacting genes:
ANP32A
ANP32B
ASF1A
ASF1B
BLM
CBX1
CBX5
CDC7
CDK2
CHAF1B
CREBBP
DBF4
DDX41
H3-4
H3C6
HMGB2
LZTR1
MBD1
MEI4
MSH6
NOTO
PABPC1
PAX6
PCBD2
PCNA
POU6F2
RBFOX2
REL
SERTAD1
SET
SPOP
STAT5B
SUMO1
SUMO2
SUMO3
TCERG1
TCF4
TRIB3
TRIM28
XRCC5
XRCC6
YWHAB
YWHAE
YWHAG
YWHAQ
ZNF408
ZNF620
Entrez ID
2956
10036
HPRD ID
07202
03148
Ensembl ID
ENSG00000116062
ENSG00000167670
Uniprot IDs
A0A494C0M1
A0A8V8TPJ4
P52701
Q3SWU9
Q13111
PDB IDs
2GFU
2O8B
2O8C
2O8D
2O8E
2O8F
6OQM
8AG6
7Y5K
7Y5L
7Y5O
7Y5U
7Y5V
7Y60
7Y61
8IQF
8IQG
8J6S
8J6T
Enriched GO Terms of Interacting Partners
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Cellular Response To Radiation
DNA Repair
DNA Damage Response
Response To Radiation
DNA Metabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Damaged DNA Binding
Response To Ionizing Radiation
Cellular Response To Ionizing Radiation
Cellular Response To Stress
Negative Regulation Of Cell Cycle Process
DNA Damage Checkpoint Signaling
Response To Stress
Nucleic Acid Metabolic Process
Regulation Of Cell Cycle
Checkpoint Clamp Complex
Nucleobase-containing Compound Metabolic Process
Signal Transduction In Response To DNA Damage
Intracellular Signal Transduction
Regulation Of Cell Cycle Phase Transition
MutLalpha Complex Binding
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Regulation Of Cell Cycle Process
Regulation Of Cellular Response To Stress
Negative Regulation Of Mitotic Cell Cycle
Nucleus
DNA Recombination
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Intra-S DNA Damage Checkpoint Signaling
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
Regulation Of Transcription By RNA Polymerase II
BRCA1-BARD1 Complex
Chromatin Binding
Response To UV
Histone H3K27 Acetyltransferase Activity
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
Mitotic DNA Damage Checkpoint Signaling
Mitotic DNA Integrity Checkpoint Signaling
Intrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Catabolic Process
Histone H3K18 Acetyltransferase Activity
N-terminal Peptidyl-lysine Acetylation
Peptide Lactyltransferase (CoA-dependent) Activity
Dinucleotide Insertion Or Deletion Binding
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Catabolic Process
Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Nucleoplasm
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Chromatin Organization
DNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Remodeling
Nucleic Acid Metabolic Process
Nucleosome Assembly
DNA Repair
Regulation Of Metabolic Process
Regulation Of Gene Expression
DNA Damage Response
Negative Regulation Of RNA Metabolic Process
DNA Replication-dependent Chromatin Assembly
Protein-DNA Complex Assembly
Regulation Of Macromolecule Biosynthetic Process
Nucleosome Organization
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Chromatin
DNA Recombination
Regulation Of Transcription By RNA Polymerase II
Chromosome, Telomeric Region
Damaged DNA Binding
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Chromatin Binding
Cellular Response To Stress
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein-containing Complex
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
DNA Binding
Chromosome Organization
Positive Regulation Of Macromolecule Metabolic Process
Macromolecule Metabolic Process
Telomere Organization
ATP-dependent Activity, Acting On DNA
Ubiquitin Protein Ligase Binding
Chromosome
Positive Regulation Of Metabolic Process
Recombinational Repair
Double-strand Break Repair
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Tagcloud (Intersection)
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