MSH6 and SMC1A

Number of citations of the paper that reports this interaction (PubMedID 14657349)
27

Data Source:
BioGRID (pull down)

		MSH6	SMC1A
Description		mutS homolog 6	structural maintenance of chromosomes 1A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Golgi Apparatus Cytosol MutSalpha Complex	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Mitotic Cohesin Complex Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Four-way Junction DNA Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding Histone H3K36me3 Reader Activity ATP-dependent DNA Damage Sensor Activity	Nucleotide Binding DNA Binding Chromatin Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Mediator Complex Binding Protein Heterodimerization Activity
	Biological Process	Meiotic Mismatch Repair DNA Repair Mismatch Repair Chromatin Organization DNA Damage Response Spermatogenesis Determination Of Adult Lifespan Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Intrinsic Apoptotic Signaling Pathway	Mitotic Sister Chromatid Segregation DNA Repair DNA Damage Response Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Response To Radiation Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Somatic Stem Cell Population Maintenance Chromosome Organization Cell Division Meiotic Cell Cycle Response To DNA Damage Checkpoint Signaling Mitotic Spindle Assembly
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Colorectal cancer	Cornelia de Lange syndrome (CdLS)
GWAS		General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Menopause (age at onset) ( 26414677) Takayasu arteritis ( 25604533) Tea consumption ( 31046077)	Bipolar disorder ( 31043756) Mean corpuscular volume ( 32888494)
Interacting Genes		20 interacting genes: BARD1 BRCA1 CEBPA CHAF1A CREBBP CSNK2A1 EP300 HRAS HUS1 MAP2K1 MSH2 MUTYH NANS PCNA PTEN RAD1 RAD9A SMC1A SUMO2 WEE2-AS1	22 interacting genes: AMOT ATM BLM BRCA1 CEBPA ESR1 FGF14 ITSN1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3 SUMO2
Entrez ID		2956	8243
HPRD ID		07202	02077
Ensembl ID		ENSG00000116062	ENSG00000072501
Uniprot IDs		A0A494C0M1 A0A8V8TPJ4 P52701 Q3SWU9	A0A384MR33 G8JLG1 Q14683 Q68EN4
PDB IDs		2GFU 2O8B 2O8C 2O8D 2O8E 2O8F 6OQM 8AG6	6WG3 6WG4 6WG6 6WGE 7W1M 8P0A 8PQ5 8RO6 8RO7 8RO8 8RO9 8ROA 8ROB 8ROC 8ROD 8ROE 8ROF 8ROG
Enriched GO Terms of Interacting Partners?		Cellular Response To Radiation DNA Repair DNA Damage Response Response To Radiation DNA Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Damaged DNA Binding Response To Ionizing Radiation Cellular Response To Ionizing Radiation Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Response To Stress Nucleic Acid Metabolic Process Regulation Of Cell Cycle Checkpoint Clamp Complex Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition MutLalpha Complex Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Cell Cycle Process Regulation Of Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Nucleus DNA Recombination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Transcription By RNA Polymerase II BRCA1-BARD1 Complex Chromatin Binding Response To UV Histone H3K27 Acetyltransferase Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Catabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Dinucleotide Insertion Or Deletion Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process	Chromosome DNA Repair DNA Metabolic Process DNA Damage Response Double-strand Break Repair DNA Recombination Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Stress Nuclear Matrix Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Recombinational Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Single-stranded DNA Binding Nucleoplasm Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Recombination Intracellular Signal Transduction Lateral Element Regulation Of DNA Recombination Regulation Of Cell Cycle Phase Transition DNA Replication Four-way Junction DNA Binding Signal Transduction In Response To DNA Damage Single Thymine Insertion Binding MutSalpha Complex Chromatin Binding Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Chromosome Separation Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Chromosome, Telomeric Region Regulation Of Metabolic Process DNA Binding Nucleotide Binding Regulation Of Cell Cycle ATP Binding Single Guanine Insertion Binding Establishment Of Meiotic Sister Chromatid Cohesion
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