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NKX3-2 and SMAD1
Number of citations of the paper that reports this interaction (PubMedID
14612411
)
77
Data Source:
BioGRID
(pull down, pull down, affinity chromatography technology)
NKX3-2
SMAD1
Description
NK3 homeobox 2
SMAD family member 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Chromatin
Male Germ Cell Nucleus
Nucleus
Nuclear Inner Membrane
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Membrane
Protein-containing Complex
SMAD Protein Complex
Homomeric SMAD Protein Complex
Heteromeric SMAD Protein Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
DEAD/H-box RNA Helicase Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
Primary MiRNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Determination Of Left/right Symmetry
Cell Differentiation
Pancreas Development
Negative Regulation Of Chondrocyte Differentiation
Middle Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Animal Organ Development
Spleen Development
Animal Organ Formation
Skeletal System Morphogenesis
Embryonic Skeletal System Development
Digestive System Development
Intestinal Epithelial Cell Development
MAPK Cascade
Ossification
Osteoblast Differentiation
Ureteric Bud Development
Mesodermal Cell Fate Commitment
Osteoblast Fate Commitment
Cardiac Conduction System Development
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Gamete Generation
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Embryonic Pattern Specification
Positive Regulation Of Gene Expression
Cell Differentiation
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Primary MiRNA Processing
Developmental Process
Homeostatic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Stem Cell Differentiation
Negative Regulation Of Muscle Cell Differentiation
Cartilage Development
Cardiac Muscle Cell Proliferation
Bone Development
SMAD Protein Signal Transduction
Positive Regulation Of Cartilage Development
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Dendrite Development
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Sprouting Angiogenesis
Anti-Mullerian Hormone Receptor Signaling Pathway
Pathways
Regulation of RUNX2 expression and activity
Signaling by BMP
Ub-specific processing proteases
RUNX2 regulates bone development
Cardiogenesis
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases
Spondylo-megaepiphyseal-metaphyseal dysplasia
GWAS
Metabolite levels (
23823483
)
Periodontal disease-related phenotype (Socransky) (
24347629
)
HDL cholesterol levels (
32203549
)
Hemoglobin (
32888494
)
Lung function (FEV1) (
30061609
)
Malaria (
31844061
)
Midgestational cytokine/chemokine levels (maternal genetic effect) (
30134952
)
Panic disorder (
31712720
)
Red cell distribution width (
32888494
)
Response to cognitive-behavioural therapy in anxiety disorder (
26989097
)
Interacting Genes
4 interacting genes:
HDAC1
POU6F2
SMAD1
SMAD4
163 interacting genes:
ACVR1
ACVRL1
AKR1B1
ANKRD27
AP2A2
APC
APP
AR
ARHGEF6
ARL4D
AXIN2
BMPR1A
BTBD2
BTG2
BUB1
CAMSAP1
CCND1
CDK7
CDK9
CHMP3
CILK1
COL4A1
CREBBP
CTNNA1
DACH1
DLC1
DNMT3L
DVL1
ECSIT
EIF2AK4
ELP3
EP300
EPN2
ERBB2
ERBIN
EWSR1
FBXL12
FBXO30
FBXW7
FHL5
FOXG1
FRZB
GDF6
GLI3
GMEB1
GSC
HBP1
HIPK2
HOXA13
HOXA5
HOXC8
HOXD13
ING2
INPP4A
IRF2BP1
KAT2B
KMT2D
LEF1
LEMD3
LMNA
MAP2K3
MAPK1
MAST4
MBD1
MECOM
MED6
MEN1
MGA
MLH1
MLH3
MRTFB
MSH2
MUTYH
NAT9
NEDD4
NEDD9
NEUROG1
NFE2L2
NKX3-2
NOTCH2
NRAS
OAZ1
OAZ3
PAK1
PARD3
PDGFRL
PIAS1
PIAS4
PIGQ
PLEKHB1
PREB
PSMB4
PSMD1
PSMD11
PTPN12
PUM1
RAB2B
RAB30
RAB34
RAB38
RAB3B
RAB6B
RAC2
RAN
RAP2A
RASD2
RASL12
RFX1
RHEBL1
RHOG
RPS27A
SF3B1
SKI
SKIL
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMARCE1
SMURF1
SMURF2
SNIP1
SNRNP70
SOX5
SQSTM1
SS18L1
STARD13
STK11
STUB1
SUV39H1
TAPT1
TCF20
TET2
TGFBR1
TLR2
TNNT1
TOB1
TRIP6
TTF1
TTF2
UBA52
UBC
UBE2Z
UBXN1
USP45
VEPH1
WDR77
XPC
XPO1
YAP1
YY1
ZBTB44
ZDHHC3
ZEB2
ZNF251
ZNF423
ZNF510
ZNF512B
ZNF521
ZNF76
ZNF8
ZSCAN4
Entrez ID
579
4086
HPRD ID
09075
03356
Ensembl ID
ENSG00000109705
ENSG00000170365
Uniprot IDs
P78367
Q15797
PDB IDs
1KHU
2LAW
2LAX
2LAY
2LAZ
2LB0
2LB1
3Q47
3Q4A
5ZOK
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Muscle Cell Differentiation
Heteromeric SMAD Protein Complex
SMAD Protein Complex
Regulation Of Muscle Cell Differentiation
I-SMAD Binding
Cardiac Conduction System Development
SMAD Protein Signal Transduction
Transcription Regulator Complex
Endoderm Development
Cellular Response To Growth Factor Stimulus
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Striated Muscle Cell Differentiation
Response To Growth Factor
Chromatin
Transcription Corepressor Binding
Embryonic Digit Morphogenesis
Positive Regulation Of MiRNA Transcription
Embryonic Pattern Specification
Cardiac Muscle Tissue Development
Positive Regulation Of MiRNA Metabolic Process
Intracellular Iron Ion Homeostasis
Regulation Of MiRNA Transcription
Regulation Of Striated Muscle Cell Differentiation
Regulation Of MiRNA Metabolic Process
BMP Signaling Pathway
Negative Regulation Of Cardiac Myofibril Assembly
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Female Gonad Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
Stem Cell Differentiation
Krueppel-associated Box Domain Binding
Negative Regulation Of Cell Differentiation
Striated Muscle Tissue Development
Osteoblast Differentiation
Homomeric SMAD Protein Complex
DNA-binding Transcription Factor Activity
Gonad Morphogenesis
Nephrogenic Mesenchyme Morphogenesis
Negative Regulation Of Canonical Wnt Signaling Pathway
Tissue Development
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Protein-containing Complex
Protein Lysine Delactylase Activity
Fungiform Papilla Formation
Mesodermal Cell Fate Commitment
Muscle Tissue Development
Osteoblast Fate Commitment
Activin Responsive Factor Complex
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Metanephric Mesenchyme Morphogenesis
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Primary Metabolic Process
Nucleoplasm
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Nucleus
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Developmental Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
SMAD Binding
Regulation Of Gene Expression
Pattern Specification Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Differentiation
Regionalization
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Anterior/posterior Pattern Specification
Negative Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Multicellular Organismal Process
Chromatin Binding
DNA Binding
Cellular Developmental Process
I-SMAD Binding
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Developmental Process
Embryonic Morphogenesis
Negative Regulation Of Developmental Process
Negative Regulation Of Metabolic Process
Regulation Of Multicellular Organismal Development
Anatomical Structure Morphogenesis
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Tagcloud (Intersection)
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