NKX3-2

Description		NK3 homeobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Determination Of Left/right Symmetry Cell Differentiation Pancreas Development Negative Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Negative Regulation Of Apoptotic Process Animal Organ Development Spleen Development Animal Organ Formation Skeletal System Morphogenesis Embryonic Skeletal System Development Digestive System Development Intestinal Epithelial Cell Development
Pathways		Regulation of RUNX2 expression and activity
Drugs
Diseases		Spondylo-megaepiphyseal-metaphyseal dysplasia
GWAS		Metabolite levels ( 23823483) Periodontal disease-related phenotype (Socransky) ( 24347629)
Novel Interacting Genes		1 novel interacting genes: GRPEL1
Interacting Genes		4 interacting genes: HDAC1 POU6F2 SMAD1 SMAD4
Entrez ID		579
HPRD ID		09075
Ensembl ID		ENSG00000109705
Uniprot IDs		P78367
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Muscle Cell Differentiation Heteromeric SMAD Protein Complex SMAD Protein Complex Regulation Of Muscle Cell Differentiation I-SMAD Binding Cardiac Conduction System Development SMAD Protein Signal Transduction Transcription Regulator Complex Endoderm Development Cellular Response To Growth Factor Stimulus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Striated Muscle Cell Differentiation Response To Growth Factor Chromatin Transcription Corepressor Binding Embryonic Digit Morphogenesis Positive Regulation Of MiRNA Transcription Embryonic Pattern Specification Cardiac Muscle Tissue Development Positive Regulation Of MiRNA Metabolic Process Intracellular Iron Ion Homeostasis Regulation Of MiRNA Transcription Regulation Of Striated Muscle Cell Differentiation Regulation Of MiRNA Metabolic Process BMP Signaling Pathway Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Stem Cell Differentiation Krueppel-associated Box Domain Binding Negative Regulation Of Cell Differentiation Striated Muscle Tissue Development Osteoblast Differentiation Homomeric SMAD Protein Complex DNA-binding Transcription Factor Activity Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein-containing Complex Protein Lysine Delactylase Activity Fungiform Papilla Formation Mesodermal Cell Fate Commitment Muscle Tissue Development Osteoblast Fate Commitment Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis
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