PTPRD and TMEM132D

Number of citations of the paper that reports this interaction (PubMedID 33726789)
50

Data Source:
BioGRID (two hybrid)

		PTPRD	TMEM132D
Description		protein tyrosine phosphatase receptor type D	transmembrane protein 132D
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Presynaptic Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Cell Adhesion Molecule Binding	Protein Binding
	Biological Process	Phosphate-containing Compound Metabolic Process Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Dendrite Morphogenesis Regulation Of Immune Response Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Presynaptic Membrane Assembly Presynapse Assembly Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion
Pathways		Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Anxiety and major depressive disorder ( 24047446) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bitter alcoholic beverage consumption ( 31046077) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Cardiac Troponin-T levels ( 31014085) Cardiorespiratory fitness (800m run time) ( 32572135) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) DHEAS levels ( 34748635) Diastolic blood pressure ( 30224653) Early age at menarche ( 29773799) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Epilepsy (remission after treatment) ( 23962720) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Femur bone mineral density x serum urate levels interaction ( 34046847) Gait rhythm ( 26219847) Glycine levels ( 31070104) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Intracranial aneurysm ( 29531279) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lean body mass ( 28552196) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 29773799 25231870) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Moderate-to-late spontaneous preterm birth ( 31194736) Modic changes ( 30808802) Mood instability ( 29187730) Morning person ( 30696823) Myopia (pathological) ( 23049088) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Non-response to antidepressants and depression ( 27622933) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 24821223) Obsessive-compulsive traits ( 33531474) Opioid use cessation ( 31936517) Palmitic acid (16:0) levels ( 23362303) Parkinson's disease progression (motor) ( 33111402) Partial epilepsies ( 20522523) Pelvic organ prolapse (moderate/severe) ( 26545240) Personality dimensions ( 23903073) Pit-and-Fissure caries ( 24556642) Plasma clusterin levels ( 26545630) Platelet aggregation ( 20526338) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Resistant hypertension ( 30237584) Resting-state electroencephalogram vigilance ( 29703947) Restless legs syndrome ( 18660810 33239738 29029846 21779176) Short-term memory (digit-span task) ( 30741946) Smoking initiation ( 33082346) spontaneous preterm birth x maternal stress interaction (1df) ( 32726798) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure ( 30224653 27841878) Temperament ( 22832960) Third ventricle volume ( 31530798) Triglyceride levels ( 34074324) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 21647700 20174558) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anxiety disorder ( 25390645) Asthma ( 29273806) Blood protein levels ( 30072576) Body fat mass ( 28552196) Cognitive decline rate in late mild cognitive impairment ( 26252872) Heart rate ( 23534349) Initial pursuit acceleration ( 29064472) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Retinal venular tortuosity ( 31597446) Schizophrenia (inflammation and infection response interaction) ( 25781172) Sleep (1/2-day periodicity) ( 33075057) Triglyceride levels ( 34074324) Trunk fat mass ( 28552196) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		42 interacting genes: ABLIM1 AURKA BMX CSNK1D CSNK1E DDX17 DDX54 EPHA8 ERG GPC4 GRIK1 HUNK IL1RAP IRS1 KCNJ6 MARK2 MATK MTNR1A MTNR1B MTSS1 NEK1 NEK2 NEK6 OMG PAK6 PLK1 PPFIA1 PPFIA2 PPFIA3 PTPRA PTPRE PTPRF PTPRS RCAN1 RSPH1 SCEL SLAIN2 SLITRK1 SMTNL2 TBK1 TMEM132D TSSK2	70 interacting genes: ANKRD31 ANKRD36 ARL3 ATP1B1 ATP7A BNIP3L CADPS2 CCDC85A CD59 CMPK1 CNGB3 CNTN1 COMMD1 COX11 CPD EFEMP1 ENOPH1 FAM106A FMO2 GFM2 H3C1 HDAC2 HEBP2 HNRNPUL1 HOXA9 IDI2-AS1 IL13RA1 LNX1 MIR181A1HG MME NAMPT NCKAP1 NDUFS5 NPAS3 PAIP1 PCCA PCLO PGM1 PLSCR2 PNISR PRMT3 PRPF40A PTPN2 PTPRD RAB6A RCBTB2 RNF2 SAMD12 SDHB SEC22B SHLD2 SLC35E2A SRSF5 STK39 SVIL TCF12 TMED5 TMED7-TICAM2 TNFAIP8 TOB2 TPST1 TRAPPC11 TRAPPC8 TUBGCP5 UBA5 UMOD USP32P2 VPS13C ZBTB20 ZNF302
Entrez ID		5789	121256
HPRD ID		03358	13906
Ensembl ID		ENSG00000153707	ENSG00000151952
Uniprot IDs		P23468 Q2HXI4 Q3KPI9 Q59H90	Q14C87
PDB IDs		1X5Z 2DLH 2YD6 2YD7 4RCA 5WY8 5XNP 6X3A
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Phosphorylation Phosphorylation Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Synaptic Membrane Adhesion ATP Binding Phosphate-containing Compound Metabolic Process Nucleotide Binding Protein Autophosphorylation Protein Modification Process Microtubule Cytoskeleton Organization Signal Transduction Cytoskeleton Organization Centrosome Separation Peptidyl-serine Phosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Transferase Activity Protein Localization To Centrosome Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Melatonin Receptor Activity Spindle Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Projection Organization Spindle Assembly Mitotic Spindle Organization Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Microtubule-based Process Presynaptic Active Zone Spindle Microtubule Cytoskeleton Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Proteasomal Protein Catabolic Process Cell Surface Receptor Signaling Pathway Protein Localization To Cytoskeleton Plasma Membrane Bounded Cell Projection Organization Protein Tyrosine Kinase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Nuclear Membrane Disassembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Phosphoprotein Phosphatase Activity Synapse Organization Postsynaptic Density Glutamatergic Synapse	Golgi Vesicle Transport Protein Transport Into Plasma Membrane Raft Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process ATP Metabolic Process Nucleoside Phosphate Metabolic Process Protein Transport Into Membrane Raft Positive Regulation Of Potassium Ion Import Across Plasma Membrane Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Purine-containing Compound Metabolic Process Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transport
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