TMEM132D and IL13RA1

Number of citations of the paper that reports this interaction (PubMedID 33726789)
50

Data Source:
BioGRID (two hybrid)

		TMEM132D	IL13RA1
Description		transmembrane protein 132D	interleukin 13 receptor subunit alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Interleukin-13 Receptor Complex External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Protein Binding	Cytokine Receptor Activity Protein Binding Cytokine Binding
	Biological Process		Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway
Pathways			Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anxiety disorder ( 25390645) Asthma ( 29273806) Blood protein levels ( 30072576) Body fat mass ( 28552196) Cognitive decline rate in late mild cognitive impairment ( 26252872) Heart rate ( 23534349) Initial pursuit acceleration ( 29064472) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Retinal venular tortuosity ( 31597446) Schizophrenia (inflammation and infection response interaction) ( 25781172) Sleep (1/2-day periodicity) ( 33075057) Triglyceride levels ( 34074324) Trunk fat mass ( 28552196) Type 2 diabetes (age of onset) ( 28060188)	Body mass index ( 28892062) Type 2 diabetes ( 30718926)
Interacting Genes		70 interacting genes: ANKRD31 ANKRD36 ARL3 ATP1B1 ATP7A BNIP3L CADPS2 CCDC85A CD59 CMPK1 CNGB3 CNTN1 COMMD1 COX11 CPD EFEMP1 ENOPH1 FAM106A FMO2 GFM2 H3C1 HDAC2 HEBP2 HNRNPUL1 HOXA9 IDI2-AS1 IL13RA1 LNX1 MIR181A1HG MME NAMPT NCKAP1 NDUFS5 NPAS3 PAIP1 PCCA PCLO PGM1 PLSCR2 PNISR PRMT3 PRPF40A PTPN2 PTPRD RAB6A RCBTB2 RNF2 SAMD12 SDHB SEC22B SHLD2 SLC35E2A SRSF5 STK39 SVIL TCF12 TMED5 TMED7-TICAM2 TNFAIP8 TOB2 TPST1 TRAPPC11 TRAPPC8 TUBGCP5 UBA5 UMOD USP32P2 VPS13C ZBTB20 ZNF302	7 interacting genes: DLG4 IL13 IL4R TMEM132D TMEM39B TRAF3IP1 TYK2
Entrez ID		121256	3597
HPRD ID		13906	02125
Ensembl ID		ENSG00000151952	ENSG00000131724
Uniprot IDs		Q14C87	P78552
PDB IDs			3BPN 3BPO 4HWB 5E4E
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Transport Protein Transport Into Plasma Membrane Raft Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process ATP Metabolic Process Nucleoside Phosphate Metabolic Process Protein Transport Into Membrane Raft Positive Regulation Of Potassium Ion Import Across Plasma Membrane Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Purine-containing Compound Metabolic Process Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transport	Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Regulation Of Mast Cell Degranulation P2Y1 Nucleotide Receptor Binding Positive Regulation Of Lymphocyte Activation Regulation Of Cytokine Production Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Immunoglobulin Production Regulation Of Macrophage Activation Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Interleukin-13 Receptor Binding Negative Regulation Of Lung Ciliated Cell Differentiation Cytokine-mediated Signaling Pathway Regulation Of Immunoglobulin Production Positive Regulation Of Exocytosis Response To Other Organism Positive Regulation Of Cold-induced Thermogenesis Interleukin-4 Receptor Activity Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Regulation Of Vesicle-mediated Transport Response To External Biotic Stimulus Regulation Of Alpha-beta T Cell Activation Regulation Of Regulated Secretory Pathway Interleukin-13-mediated Signaling Pathway Interleukin-12 Receptor Complex Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Cold-induced Thermogenesis Regulation Of Cell Activation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Interleukin-23 Receptor Complex AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Leukocyte Proliferation Transforming Growth Factor Beta1 Production Regulation Of Multicellular Organismal Process NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Exocytosis Interleukin-23-mediated Signaling Pathway Positive Regulation Of NK T Cell Proliferation Morphogenesis Of A Polarized Epithelium D1 Dopamine Receptor Binding Regulation Of Production Of Molecular Mediator Of Immune Response
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