TMEM132D and UMOD

Number of citations of the paper that reports this interaction (PubMedID 33726789)
50

Data Source:
BioGRID (two hybrid)

		TMEM132D	UMOD
Description		transmembrane protein 132D	uromodulin
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Spindle Pole Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cilium Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Cell Projection Ciliary Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding IgG Binding
	Biological Process		Kidney Development Organ Or Tissue Specific Immune Response Immune System Process Renal Water Homeostasis Glomerular Filtration Lipid Metabolic Process Intracellular Calcium Ion Homeostasis Intracellular Sodium Ion Homeostasis Autophagy Apoptotic Process Inflammatory Response Cellular Defense Response Response To Unfolded Protein Endoplasmic Reticulum Organization Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation RNA Splicing Response To Xenobiotic Stimulus Response To Water Deprivation Gene Expression Urate Transport Intracellular Phosphate Ion Homeostasis Intracellular Chloride Ion Homeostasis Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Stress Multicellular Organismal Response To Stress Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Regulation Of Urine Volume ERAD Pathway Protein Transport Into Plasma Membrane Raft Innate Immune Response Citric Acid Secretion Multicellular Organismal-level Homeostasis Chemical Homeostasis Monoatomic Ion Homeostasis Defense Response To Gram-negative Bacterium Multicellular Organismal-level Water Homeostasis Regulation Of Protein Transport Phosphate Ion Homeostasis Chloride Ion Homeostasis Calcium Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Micturition Renal Sodium Ion Absorption Urea Transmembrane Transport Collecting Duct Development Juxtaglomerular Apparatus Development Loop Of Henle Development Metanephric Ascending Thin Limb Development Metanephric Distal Convoluted Tubule Development Metanephric Thick Ascending Limb Development Protein Localization To Vacuole Apoptotic Signaling Pathway Connective Tissue Replacement Renal Urate Salt Excretion Antibacterial Innate Immune Response Neutrophil Migration
Pathways			Asparagine N-linked glycosylation
Drugs
Diseases			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anxiety disorder ( 25390645) Asthma ( 29273806) Blood protein levels ( 30072576) Body fat mass ( 28552196) Cognitive decline rate in late mild cognitive impairment ( 26252872) Heart rate ( 23534349) Initial pursuit acceleration ( 29064472) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Retinal venular tortuosity ( 31597446) Schizophrenia (inflammation and infection response interaction) ( 25781172) Sleep (1/2-day periodicity) ( 33075057) Triglyceride levels ( 34074324) Trunk fat mass ( 28552196) Type 2 diabetes (age of onset) ( 28060188)	Chronic kidney disease ( 20383146 29124443 26831199) Chronic kidney disease and serum creatinine levels ( 20686651) Chronic kidney disease x type 2 diabetes interaction ( 32541925) Creatinine levels ( 29124443) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (ever vs never) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31015462 30604766 29124443) Estimated glomerular filtration rate (creatinine, CKDi25) ( 33137338) Estimated glomerular filtration rate (creatinine, Rapid3) ( 33137338) Femoral neck bone geometry ( 22087292) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate (cystatin C) ( 28452372) Glomerular filtration rate in diabetes ( 29703844) Glomerular filtration rate in diabetics (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glomerular filtration rate in type 2 diabetes ( 29703844) Hypertension ( 27618447 21082022) Hyperuricemia ( 29124443) Kidney function decline traits ( 25493955) Kidney stones ( 31729369) Medication use (calcium channel blockers) ( 31015401) Renal function and chronic kidney disease ( 19430482) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum uric acid levels ( 29124443) Type 1 diabetes ( 34127860) Urate levels ( 31578528) Urinary uromodulin levels ( 24578125)
Interacting Genes		70 interacting genes: ANKRD31 ANKRD36 ARL3 ATP1B1 ATP7A BNIP3L CADPS2 CCDC85A CD59 CMPK1 CNGB3 CNTN1 COMMD1 COX11 CPD EFEMP1 ENOPH1 FAM106A FMO2 GFM2 H3C1 HDAC2 HEBP2 HNRNPUL1 HOXA9 IDI2-AS1 IL13RA1 LNX1 MIR181A1HG MME NAMPT NCKAP1 NDUFS5 NPAS3 PAIP1 PCCA PCLO PGM1 PLSCR2 PNISR PRMT3 PRPF40A PTPN2 PTPRD RAB6A RCBTB2 RNF2 SAMD12 SDHB SEC22B SHLD2 SLC35E2A SRSF5 STK39 SVIL TCF12 TMED5 TMED7-TICAM2 TNFAIP8 TOB2 TPST1 TRAPPC11 TRAPPC8 TUBGCP5 UBA5 UMOD USP32P2 VPS13C ZBTB20 ZNF302	4 interacting genes: LINC02582 LTA MMP8 TMEM132D
Entrez ID		121256	7369
HPRD ID		13906	11771
Ensembl ID		ENSG00000151952	ENSG00000169344
Uniprot IDs		Q14C87	P07911
PDB IDs			4WRN 6TQK 6TQL 6ZS5 6ZYA 7PFP 7Q3N
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Transport Protein Transport Into Plasma Membrane Raft Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process ATP Metabolic Process Nucleoside Phosphate Metabolic Process Protein Transport Into Membrane Raft Positive Regulation Of Potassium Ion Import Across Plasma Membrane Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Purine-containing Compound Metabolic Process Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transport	Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Positive Regulation Of Chronic Inflammatory Response Regulation Of Chronic Inflammatory Response Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response Positive Regulation Of Microglial Cell Activation Tumor Necrosis Factor Binding
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