TMEM132D and ATP7A

Number of citations of the paper that reports this interaction (PubMedID 33726789)
50

Data Source:
BioGRID (two hybrid)

		TMEM132D	ATP7A
Description		transmembrane protein 132D	ATPase copper transporting alpha
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Cytoplasm Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Trans-Golgi Network Transport Vesicle Axon Dendrite Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Trans-Golgi Network Membrane Melanosome Membrane Cell Projection Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Bounding Membrane Of Organelle
	Molecular Function	Protein Binding	Nucleotide Binding Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding P-type Ion Transporter Activity Superoxide Dismutase Copper Chaperone Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Copper-dependent Protein Binding P-type Divalent Copper Transporter Activity Metal Ion Binding P-type Monovalent Copper Transporter Activity Cuprous Ion Binding
	Biological Process		Blood Vessel Development Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Regulation Of Oxidative Phosphorylation L-tryptophan Metabolic Process Tyrosine Metabolic Process Catecholamine Metabolic Process Monoatomic Ion Transport Monoatomic Cation Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Mitochondrion Organization Locomotory Behavior Glycoprotein Biosynthetic Process Detoxification Of Copper Ion Regulation Of Gene Expression Copper Ion Import Removal Of Superoxide Radicals Cerebellar Purkinje Cell Differentiation Pyramidal Neuron Development Central Nervous System Neuron Development Extracellular Matrix Organization Collagen Fibril Organization Hair Follicle Morphogenesis T-helper Cell Differentiation Epinephrine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Norepinephrine Biosynthetic Process Serotonin Metabolic Process Pigmentation Negative Regulation Of Neuron Apoptotic Process Skin Development Negative Regulation Of Catecholamine Metabolic Process ATP Metabolic Process Positive Regulation Of Melanin Biosynthetic Process Elastic Fiber Assembly Lung Alveolus Development Neuron Projection Morphogenesis Dendrite Morphogenesis Cartilage Development Neuron Apoptotic Process Establishment Of Localization In Cell Copper Ion Export Neuron Cellular Homeostasis
Pathways			Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface Ion transport by P-type ATPases
Drugs
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Menkes disease (MD); Menkes kinky hair syndrome Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Distal hereditary motor neuropathies (dHMN)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anxiety disorder ( 25390645) Asthma ( 29273806) Blood protein levels ( 30072576) Body fat mass ( 28552196) Cognitive decline rate in late mild cognitive impairment ( 26252872) Heart rate ( 23534349) Initial pursuit acceleration ( 29064472) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Retinal venular tortuosity ( 31597446) Schizophrenia (inflammation and infection response interaction) ( 25781172) Sleep (1/2-day periodicity) ( 33075057) Triglyceride levels ( 34074324) Trunk fat mass ( 28552196) Type 2 diabetes (age of onset) ( 28060188)	Height ( 31562340)
Interacting Genes		70 interacting genes: ANKRD31 ANKRD36 ARL3 ATP1B1 ATP7A BNIP3L CADPS2 CCDC85A CD59 CMPK1 CNGB3 CNTN1 COMMD1 COX11 CPD EFEMP1 ENOPH1 FAM106A FMO2 GFM2 H3C1 HDAC2 HEBP2 HNRNPUL1 HOXA9 IDI2-AS1 IL13RA1 LNX1 MIR181A1HG MME NAMPT NCKAP1 NDUFS5 NPAS3 PAIP1 PCCA PCLO PGM1 PLSCR2 PNISR PRMT3 PRPF40A PTPN2 PTPRD RAB6A RCBTB2 RNF2 SAMD12 SDHB SEC22B SHLD2 SLC35E2A SRSF5 STK39 SVIL TCF12 TMED5 TMED7-TICAM2 TNFAIP8 TOB2 TPST1 TRAPPC11 TRAPPC8 TUBGCP5 UBA5 UMOD USP32P2 VPS13C ZBTB20 ZNF302	4 interacting genes: ATOX1 CP PDZD11 TMEM132D
Entrez ID		121256	538
HPRD ID		13906	02054
Ensembl ID		ENSG00000151952	ENSG00000165240
Uniprot IDs		Q14C87	B4DRW0 Q04656 Q762B6
PDB IDs			1AW0 1KVI 1KVJ 1Q8L 1S6O 1S6U 1Y3J 1Y3K 1YJR 1YJT 1YJU 1YJV 2AW0 2G9O 2GA7 2K1R 2KIJ 2KMV 2KMX 3CJK 5T7L 7LU8
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Transport Protein Transport Into Plasma Membrane Raft Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process ATP Metabolic Process Nucleoside Phosphate Metabolic Process Protein Transport Into Membrane Raft Positive Regulation Of Potassium Ion Import Across Plasma Membrane Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Purine-containing Compound Metabolic Process Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transport	Copper Ion Homeostasis Intracellular Copper Ion Homeostasis Copper Ion Binding Metallochaperone Activity Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Copper-dependent Protein Binding Copper Ion Export Ferroxidase Activity Oxidoreductase Activity, Acting On Metal Ions Copper Chaperone Activity Phospholipid-hydroperoxide Glutathione Peroxidase Activity Copper Ion Transmembrane Transport Cuprous Ion Binding Regulation Of Synaptic Assembly At Neuromuscular Junction Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Copper Ion Transport Pore Complex Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Pore Complex Assembly Glutathione Peroxidase Activity Intracellular Chemical Homeostasis Cellular Homeostasis Synaptic Vesicle Transport Neurotransmitter Secretion Chemical Homeostasis
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