PTPRD and DDX17

Number of citations of the paper that reports this interaction (PubMedID 22305495)
32

Data Source:
BioGRID (pull down)

		PTPRD	DDX17
Description		protein tyrosine phosphatase receptor type D	DEAD-box helicase 17
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Presynaptic Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Ribonucleoprotein Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Cell Adhesion Molecule Binding	Nucleotide Binding Nucleic Acid Binding Transcription Coactivator Activity RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Phosphate-containing Compound Metabolic Process Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Dendrite Morphogenesis Regulation Of Immune Response Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Presynaptic Membrane Assembly Presynapse Assembly Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Epithelial To Mesenchymal Transition Immune System Process Regulation Of Transcription By RNA Polymerase II RRNA Processing RNA Processing MRNA Processing RNA Splicing MiRNA Metabolic Process Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Regulatory NcRNA-mediated Gene Silencing Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules	SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Anxiety and major depressive disorder ( 24047446) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bitter alcoholic beverage consumption ( 31046077) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Cardiac Troponin-T levels ( 31014085) Cardiorespiratory fitness (800m run time) ( 32572135) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) DHEAS levels ( 34748635) Diastolic blood pressure ( 30224653) Early age at menarche ( 29773799) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Epilepsy (remission after treatment) ( 23962720) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Femur bone mineral density x serum urate levels interaction ( 34046847) Gait rhythm ( 26219847) Glycine levels ( 31070104) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Intracranial aneurysm ( 29531279) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lean body mass ( 28552196) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 29773799 25231870) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Moderate-to-late spontaneous preterm birth ( 31194736) Modic changes ( 30808802) Mood instability ( 29187730) Morning person ( 30696823) Myopia (pathological) ( 23049088) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Non-response to antidepressants and depression ( 27622933) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 24821223) Obsessive-compulsive traits ( 33531474) Opioid use cessation ( 31936517) Palmitic acid (16:0) levels ( 23362303) Parkinson's disease progression (motor) ( 33111402) Partial epilepsies ( 20522523) Pelvic organ prolapse (moderate/severe) ( 26545240) Personality dimensions ( 23903073) Pit-and-Fissure caries ( 24556642) Plasma clusterin levels ( 26545630) Platelet aggregation ( 20526338) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Resistant hypertension ( 30237584) Resting-state electroencephalogram vigilance ( 29703947) Restless legs syndrome ( 18660810 33239738 29029846 21779176) Short-term memory (digit-span task) ( 30741946) Smoking initiation ( 33082346) spontaneous preterm birth x maternal stress interaction (1df) ( 32726798) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure ( 30224653 27841878) Temperament ( 22832960) Third ventricle volume ( 31530798) Triglyceride levels ( 34074324) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 21647700 20174558) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333)	Hip index ( 34021172) Menopause (age at onset) ( 26414677) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		42 interacting genes: ABLIM1 AURKA BMX CSNK1D CSNK1E DDX17 DDX54 EPHA8 ERG GPC4 GRIK1 HUNK IL1RAP IRS1 KCNJ6 MARK2 MATK MTNR1A MTNR1B MTSS1 NEK1 NEK2 NEK6 OMG PAK6 PLK1 PPFIA1 PPFIA2 PPFIA3 PTPRA PTPRE PTPRF PTPRS RCAN1 RSPH1 SCEL SLAIN2 SLITRK1 SMTNL2 TBK1 TMEM132D TSSK2	49 interacting genes: APBB1 APP BYSL CCDC187 CEBPA CREBBP CSNK2A1 DDX5 DDX6 DRC4 EGFR ESR1 FBL FOXP1 FXR2 GRB2 HADHB HDAC1 HNRNPH1 HNRNPH3 HNRNPK LNX1 NCOA1 NCOA2 NCOA3 OGT PIN1 PRPF6 PTK6 PTPRD RBM10 RBM14 RBM15 RBM4 RBM5 RBM7 SF1 SF3B4 SFPQ SNCA SNRNP70 SNRPA SORBS3 SREK1 SUMO2 USP7 WBP11 WBP2 YWHAG
Entrez ID		5789	10521
HPRD ID		03358	10532
Ensembl ID		ENSG00000153707	ENSG00000100201
Uniprot IDs		P23468 Q2HXI4 Q3KPI9 Q59H90	A0A5H1ZRQ2 Q59F66 Q92841
PDB IDs		1X5Z 2DLH 2YD6 2YD7 4RCA 5WY8 5XNP 6X3A	6UV0 6UV1 6UV2 6UV3 6UV4
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Phosphorylation Phosphorylation Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Synaptic Membrane Adhesion ATP Binding Phosphate-containing Compound Metabolic Process Nucleotide Binding Protein Autophosphorylation Protein Modification Process Microtubule Cytoskeleton Organization Signal Transduction Cytoskeleton Organization Centrosome Separation Peptidyl-serine Phosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Transferase Activity Protein Localization To Centrosome Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Melatonin Receptor Activity Spindle Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Projection Organization Spindle Assembly Mitotic Spindle Organization Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Microtubule-based Process Presynaptic Active Zone Spindle Microtubule Cytoskeleton Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Proteasomal Protein Catabolic Process Cell Surface Receptor Signaling Pathway Protein Localization To Cytoskeleton Plasma Membrane Bounded Cell Projection Organization Protein Tyrosine Kinase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Nuclear Membrane Disassembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Phosphoprotein Phosphatase Activity Synapse Organization Postsynaptic Density Glutamatergic Synapse	Nucleoplasm MRNA Metabolic Process RNA Splicing RNA Binding RNA Metabolic Process Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process Spliceosomal Complex Regulation Of RNA Splicing RNA Processing Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Rhythmic Process Regulation Of MRNA Processing Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II MRNA Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Nuclear Speck Chromatin Remodeling Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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