PTPRC and CRB1

		PTPRC	CRB1
Description		protein tyrosine phosphatase receptor type C	crumbs cell polarity complex component 1
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Bleb Membrane Raft Synapse Extracellular Exosome Cell Periphery Side Of Membrane Membrane Microdomain	Photoreceptor Outer Segment Photoreceptor Inner Segment Extracellular Region Plasma Membrane Microvillus Cell-cell Junction Adherens Junction Membrane Apical Plasma Membrane Protein-containing Complex Subapical Complex Cell Projection Apical Junction Complex Apical Part Of Cell Glial Cell Projection
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Heparin Binding Hydrolase Activity Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Ankyrin Binding Spectrin Binding Heparan Sulfate Proteoglycan Binding	Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Natural Killer Cell Differentiation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Mediated Immunity Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Response To Gamma Radiation Regulation Of Gene Expression Dephosphorylation B Cell Differentiation T Cell Differentiation Positive Regulation Of B Cell Proliferation Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Gamma-delta T Cell Differentiation Positive Regulation Of MAPK Cascade Cell Cycle Phase Transition Plasma Membrane Raft Distribution Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Alpha-beta T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Stem Cell Development Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Microglial Cell Activation Response To Aldosterone DN2 Thymocyte Differentiation Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Blood Vessel Remodeling Plasma Membrane Organization Cell Communication Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Establishment Or Maintenance Of Cell Polarity Cell-cell Signaling Visual Perception Intracellular Protein Localization Glial Cell Differentiation Gene Expression Retina Layer Formation Signaling Photoreceptor Cell Outer Segment Organization Eye Photoreceptor Cell Development Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Photoreceptor Cell Maintenance Detection Of Light Stimulus Involved In Visual Perception Retina Development In Camera-type Eye Retina Morphogenesis In Camera-type Eye Post-embryonic Retina Morphogenesis In Camera-type Eye Membrane Organization Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Cellular Response To Light Stimulus
Pathways		Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation
Drugs
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 34103634 32296059 31619474 30929738) Asthma (adult onset) ( 30929738) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 28067908 26192919) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) LDL cholesterol levels ( 32203549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 20139978 29403010 28017375) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 33272962) Type 1 diabetes ( 34012112) Ulcerative colitis ( 24837172) Vitiligo ( 27723757) White blood cell count ( 32888494)	Anorexia nervosa ( 29155802) Asthma ( 20032318) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Feeling hurt ( 29500382) Feeling worry ( 29500382) Heel bone mineral density ( 30598549) Height ( 33713608 28552196) Inflammatory bowel disease ( 28067908) Lupus nephritis in systemic lupus erythematosus ( 24925725) Neurociticism ( 29500382) Pediatric autoimmune diseases ( 26301688) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30224653)
Interacting Genes		45 interacting genes: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MAPK1 MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 SRC TYK2 UHRF2 ZAP70
Entrez ID		5788	23418
HPRD ID		01050	05019
Ensembl ID		ENSG00000081237	ENSG00000134376
Uniprot IDs		M9MML4 P08575	A0A7D6VM04 A8K118 B7Z824 B7Z826 F5H0L2 P82279
PDB IDs		1YGR 1YGU 5FMV 5FN6 5FN7 8VSE	4UU5
Enriched GO Terms of Interacting Partners?		Leukocyte Activation Cell Surface Receptor Signaling Pathway Lymphocyte Activation Cell Activation Regulation Of Immune Response Positive Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation T Cell Costimulation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of Lymphocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune Response Immune System Process Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Signaling Pathway Immune Response Activation Of Immune Response T Cell Activation Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway T Cell Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Kinase Activity Protein Phosphorylation Regulation Of Leukocyte Proliferation Phosphorylation Immune Effector Process Signaling Receptor Binding Lymphocyte Differentiation Regulation Of Mononuclear Cell Proliferation Fc Receptor Signaling Pathway Mononuclear Cell Differentiation	Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Plasma Membrane Raft Distribution Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Microglial Cell Activation Positive Regulation Of Isotype Switching To IgG Isotypes Protein Tyrosine Kinase Inhibitor Activity DN2 Thymocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Membrane Raft Distribution Gamma-delta T Cell Differentiation Membrane Raft Localization Membrane Microdomain Bleb Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Bone Marrow Development Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Gamma-delta T Cell Differentiation Positive Thymic T Cell Selection Alpha-beta T Cell Proliferation Negative Thymic T Cell Selection Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive T Cell Selection Negative Regulation Of Macrophage Activation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Neuroinflammatory Response Response To Aldosterone Regulation Of Microglial Cell Activation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative T Cell Selection Heparan Sulfate Proteoglycan Binding Ankyrin Binding Natural Killer Cell Differentiation Gamma-delta T Cell Activation Positive Regulation Of Humoral Immune Response Thymic T Cell Selection Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of Interleukin-2 Production Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Isotype Switching Membrane Raft Organization Spectrin Binding Negative Regulation Of Receptor Signaling Pathway Via STAT T Cell Selection Stem Cell Development Positive Regulation Of T Cell Mediated Cytotoxicity
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