CRB1

Description		crumbs cell polarity complex component 1
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Extracellular Region Plasma Membrane Microvillus Cell-cell Junction Adherens Junction Membrane Apical Plasma Membrane Protein-containing Complex Subapical Complex Cell Projection Apical Junction Complex Apical Part Of Cell Glial Cell Projection
	Molecular Function	Calcium Ion Binding Protein Binding
	Biological Process	Blood Vessel Remodeling Plasma Membrane Organization Cell Communication Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Establishment Or Maintenance Of Cell Polarity Cell-cell Signaling Visual Perception Intracellular Protein Localization Glial Cell Differentiation Gene Expression Retina Layer Formation Signaling Photoreceptor Cell Outer Segment Organization Eye Photoreceptor Cell Development Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Photoreceptor Cell Maintenance Detection Of Light Stimulus Involved In Visual Perception Retina Development In Camera-type Eye Retina Morphogenesis In Camera-type Eye Post-embryonic Retina Morphogenesis In Camera-type Eye Membrane Organization Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Cellular Response To Light Stimulus
Pathways
Drugs
Diseases		Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Anorexia nervosa ( 29155802) Asthma ( 20032318) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Feeling hurt ( 29500382) Feeling worry ( 29500382) Heel bone mineral density ( 30598549) Height ( 33713608 28552196) Inflammatory bowel disease ( 28067908) Lupus nephritis in systemic lupus erythematosus ( 24925725) Neurociticism ( 29500382) Pediatric autoimmune diseases ( 26301688) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30224653)
Novel Interacting Genes		1 novel interacting genes: PTPRC
Interacting Genes
Entrez ID		23418
HPRD ID		05019
Ensembl ID		ENSG00000134376
Uniprot IDs		A0A7D6VM04 A8K118 B7Z824 B7Z826 F5H0L2 P82279
PDB IDs		4UU5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Plasma Membrane Raft Distribution Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Microglial Cell Activation Positive Regulation Of Isotype Switching To IgG Isotypes Protein Tyrosine Kinase Inhibitor Activity DN2 Thymocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Membrane Raft Distribution Gamma-delta T Cell Differentiation Membrane Raft Localization Membrane Microdomain Bleb Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Bone Marrow Development Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Gamma-delta T Cell Differentiation Positive Thymic T Cell Selection Alpha-beta T Cell Proliferation Negative Thymic T Cell Selection Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive T Cell Selection Negative Regulation Of Macrophage Activation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Neuroinflammatory Response Response To Aldosterone Regulation Of Microglial Cell Activation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative T Cell Selection Heparan Sulfate Proteoglycan Binding Ankyrin Binding Natural Killer Cell Differentiation Gamma-delta T Cell Activation Positive Regulation Of Humoral Immune Response Thymic T Cell Selection Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of Interleukin-2 Production Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Isotype Switching Membrane Raft Organization Spectrin Binding Negative Regulation Of Receptor Signaling Pathway Via STAT T Cell Selection Stem Cell Development Positive Regulation Of T Cell Mediated Cytotoxicity
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