RBAK and TXK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RBAK	TXK
Description		RB associated KRAB zinc finger	TXK tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Protein Phosphorylation Regulation Of Gene Expression Positive Regulation Of Type II Interferon Production Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Type II Interferon-mediated Signaling Pathway
Pathways			FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301) Crohn's disease ( 23128233) Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) Platelet distribution width ( 27863252 32888494)
Interacting Genes		28 interacting genes: AQP1 AR BYSL CARD9 CIB3 CRACR2A DRC4 EFEMP2 EIF1AD FGF12 L3MBTL2 LMO4 LNX1 MAGOHB NEK6 PRKG1 PRPF31 RB1 SCNM1 SLC25A10 TCAF1 TNS2 TRIM41 TSGA10 TXK ZNF121 ZNF330 ZNF648	38 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TNS4 YTHDC1 ZNF587 ZNF792 ZNF835
Entrez ID		57786	7294
HPRD ID		16296	02505
Ensembl ID		ENSG00000146587	ENSG00000074966
Uniprot IDs		Q9NYW8	P42681
PDB IDs			2DM0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Collagen Fibril Organization	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Phosphotyrosine Residue Binding ErbB-3 Class Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Intracellular Signal Transduction Basal Plasma Membrane Leukocyte Activation Ephrin Receptor Binding Positive Regulation Of Phosphorylation Protein Kinase Activity Cell Activation Signal Transduction Negative Regulation Of Immune System Process Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Ephrin Receptor Signaling Pathway Receptor Complex ERBB3:ERBB2 Complex Peptidyl-tyrosine Phosphorylation T Cell Activation Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Response To Growth Factor Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Activation Kinase Activity Immune System Process Regulation Of Cell Adhesion Schwann Cell Development Regulation Of Cell Activation Leukocyte Migration Epidermal Growth Factor Receptor Activity Positive Regulation Of Protein Phosphorylation Neuregulin Receptor Activity Regulation Of MAPK Cascade Cell Motility Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Scaffold Protein Binding Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Cell Migration
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