RBAK and FGF12

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		RBAK	FGF12
Name		RB associated KRAB zinc finger	fibroblast growth factor 12
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Space Nucleus Cytoplasm Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Metal Ion Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Sodium Channel Regulator Activity Transmembrane Transporter Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Signal Transduction JNK Cascade Cell-cell Signaling Chemical Synaptic Transmission Nervous System Development Heart Development Adult Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transport Neurogenesis Neuromuscular Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Neuronal Action Potential Regulation Of Sodium Ion Transmembrane Transport Regulation Of Voltage-gated Sodium Channel Activity
Pathways		None	Phase 0 - rapid depolarisation
GWAS		No GWAS studies recorded	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) Bipolar disorder ( 31043756 ) Fasting glucose ( 34059833 ) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821 ) HDL cholesterol levels in HIV infection ( 33109212 ) Height ( 32902719 ) Hip circumference adjusted for BMI ( 28552196 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Ileal carcinoids ( 21139019 ) Major depressive disorder ( 23377640 ) Metabolite levels ( 19043545 ) Orofacial cleft x maternal periconceptional smoking interaction (1df) ( 33937227 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) PR interval ( 32439900 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Severe influenza A (H1N1) infection ( 26379185 ) Sleep quality ( 23728906 )
Interacting Genes		28 interacting genes: AQP1 AR BYSL CARD9 CIB3 CRACR2A DRC4 EFEMP2 EIF1AD FGF12 L3MBTL2 LMO4 LNX1 MAGOHB NEK6 PRKG1 PRPF31 RB1 SCNM1 SLC25A10 TCAF1 TNS2 TRIM41 TSGA10 TXK ZNF121 ZNF330 ZNF648	25 interacting genes: APP COIL CT45A1 DACH1 DCTD DPPA2 GRIP1 IKZF1 LZTS2 MAPK13 MAPK8IP2 NEDD4 NEDD4L PJA1 RBAK RNF151 RP9 SMURF1 SRPK1 SRPK2 STAC3 THAP1 YWHAE ZNF460 ZNF79
Entrez ID		57786	2257
HPRD ID		16296	03303
Ensembl ID		ENSG00000146587	ENSG00000114279
Uniprot IDs		Q9NYW8	A0A804HIN2 C9JEN8 P61328
PDB IDs		Not available	1Q1U 4JQ0
GO Terms Enriched among Interactors		Positive Regulation Of Collagen Fibril Organization	Receptor Catabolic Process Regulation Of Monoatomic Cation Transmembrane Transport Transmembrane Transporter Binding Sodium Channel Inhibitor Activity Phosphoserine Residue Binding Receptor Metabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Internalization Negative Regulation Of Sodium Ion Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Negative Regulation Of Protein Localization Regulation Of Monoatomic Ion Transport Zinc Ion Binding Positive Regulation Of Dendrite Extension Regulation Of Membrane Potential Mating Behavior Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Low-density Lipoprotein Particle Receptor Binding Negative Regulation Of Transmembrane Transport Positive Regulation Of Receptor Internalization Protein Polyubiquitination Negative Regulation Of Potassium Ion Transport Positive Regulation Of Viral Genome Replication Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Binding Positive Regulation Of Transport Reproductive Behavior Negative Regulation Of Fibroblast Proliferation Neuromuscular Junction Development Formation Of Structure Involved In A Symbiotic Process Regulation Of Membrane Repolarization Engulfment Of Target By Autophagosome Primary Ureteric Bud Growth Regulation Of Toll-like Receptor Signaling Pathway