NEK2 and FLVCR1

		NEK2	FLVCR1
Description		NIMA related kinase 2	FLVCR choline and heme transporter 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Midbody Nuclear Lumen Protein-containing Complex Ciliary Basal Body Intercellular Bridge	Mitochondrion Mitochondrial Inner Membrane Plasma Membrane Membrane Mitochondrial Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Choline Transmembrane Transporter Activity Heme Transmembrane Transporter Activity Heme Binding Transmembrane Transporter Activity Ethanolamine Transmembrane Transporter Activity
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion	Blood Vessel Development In Utero Embryonic Development Heme Biosynthetic Process Mitochondrial Transport Intracellular Iron Ion Homeostasis Phospholipid Biosynthetic Process Choline Transport Heme Transport Erythrocyte Differentiation Ethanolamine Transport Limb Morphogenesis Multicellular Organism Growth Embryonic Digit Morphogenesis Erythrocyte Maturation Regulation Of Organ Growth Spleen Development Embryonic Skeletal System Morphogenesis Transmembrane Transport Head Morphogenesis Heme Export
Pathways		APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Drugs		5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Fostamatinib
Diseases			Posterior column ataxia with retinitis pigmentosa (PCARP)
GWAS		Red cell distribution width ( 27863252 28957414 32888494) Serum alkaline phosphatase levels ( 33547301)	Asthma (childhood onset) ( 30929738) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)
Interacting Genes		29 interacting genes: CDC20 CEP250 CHGA CIP2A CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PIN1 PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3
Entrez ID		4751	28982
HPRD ID		04953	16451
Ensembl ID		ENSG00000117650	ENSG00000162769
Uniprot IDs		F6U4U2 P51955	B2RB38 Q9Y5Y0
PDB IDs		2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6SGD 6SGH 6SGI 6SGK 6SK9 6TM5	8QCS 8QCT 8R8T 8UBW 8UBX 8UBY 8UBZ 8UC0
Enriched GO Terms of Interacting Partners?		Centrosome Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Ciliary Basal Body Positive Regulation Of Microtubule Nucleation Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Ubiquitin Ligase Activator Activity Positive Regulation Of Organelle Organization Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Checkpoint Regulation Of Microtubule Nucleation Neuron Cellular Homeostasis Regulation Of Centriole-centriole Cohesion Neuronal Cell Body Axon Initial Segment Regulation Of Nuclear Division Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Cell Cycle Phase Transition Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Spindle Pole Regulation Of Cell Cycle Acinar Cell Differentiation Synapse Organization Chromosome, Centromeric Region Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Microtubule Polymerization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Hematopoietic Or Lymphoid Organ Development Cell Division Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Trachea Formation PTW/PP1 Phosphatase Complex Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Cytoskeleton Cytosol Regulation Of Circadian Rhythm	Negative Regulation Of Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Regulation Of Mitotic Centrosome Separation Centrosome Separation Condensed Chromosome Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Sister Chromatid Segregation Nuclear Lumen Blastocyst Development Condensed Nuclear Chromosome Nuclear Chromosome Segregation Sister Chromatid Segregation Mitotic Spindle Assembly Positive Regulation Of Telomere Maintenance Protein Phosphatase Binding Mitotic Spindle Organization Spindle Assembly Intercellular Bridge Meiotic Cell Cycle Spindle Organization Chromosome, Centromeric Region Chromosome Segregation Protein Autophosphorylation Positive Regulation Of Chromosome Organization Regulation Of Nuclear Division Regulation Of Mitotic Nuclear Division Spindle Pole Regulation Of Telomere Maintenance Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Cell Cycle Kinetochore Midbody Microtubule Cytoskeleton Regulation Of Chromosome Organization Negative Regulation Of Cell Cycle Process Positive Regulation Of DNA Metabolic Process Membraneless Organelle Assembly
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