NEK2 and CD46

		NEK2	CD46
Description		NIMA related kinase 2	CD46 molecule
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Midbody Nuclear Lumen Protein-containing Complex Ciliary Basal Body Intercellular Bridge	Inner Acrosomal Membrane Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity	Virus Receptor Activity Protein Binding Signaling Receptor Activity Cadherin Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion	Adaptive Immune Response Immune System Process T Cell Mediated Immunity Complement Activation, Classical Pathway Single Fertilization Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Interleukin-10 Production Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Regulation Of Immune Response Positive Regulation Of Transforming Growth Factor Beta Production
Pathways		APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GSK3B-mediated proteasomal degradation of PD-L1(CD274)	Regulation of Complement cascade
Drugs		5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Fostamatinib
Diseases
GWAS		Red cell distribution width ( 27863252 28957414 32888494) Serum alkaline phosphatase levels ( 33547301)	Age-related macular degeneration ( 23326517) Biomedical quantitative traits ( 19396169) Chronic central serous retinopathy ( 30073298) Drug experimentation measurement ( 30718321) Early age-related macular degeneration ( 32843070) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Heart rate ( 23583979) Immune response to measles vaccine (measles-specific neutralising antibody titre) ( 28289848) Keratoconus ( 33649486) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Refractive error ( 32231278) Resting heart rate ( 29769521 27798624) Schizophrenia ( 29483656 25056061) Systolic blood pressure ( 27841878 30578418) White blood cell count ( 32888494)
Interacting Genes		29 interacting genes: CDC20 CEP250 CHGA CIP2A CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PIN1 PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3	14 interacting genes: AGR3 ANKRD46 C3 DLG4 GPR37L1 ITGB1 LLGL1 MGAT5B MSN POU4F2 SRC TSPAN4 VTI1B YES1
Entrez ID		4751	4179
HPRD ID		04953	00406
Ensembl ID		ENSG00000117650	ENSG00000117335
Uniprot IDs		F6U4U2 P51955	A0A8Q3WLA6 P15529
PDB IDs		2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6SGD 6SGH 6SGI 6SGK 6SK9 6TM5	1CKL 2O39 3INB 3L89 3O8E 5FO8 8QK3
Enriched GO Terms of Interacting Partners?		Centrosome Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Ciliary Basal Body Positive Regulation Of Microtubule Nucleation Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Ubiquitin Ligase Activator Activity Positive Regulation Of Organelle Organization Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Checkpoint Regulation Of Microtubule Nucleation Neuron Cellular Homeostasis Regulation Of Centriole-centriole Cohesion Neuronal Cell Body Axon Initial Segment Regulation Of Nuclear Division Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Cell Cycle Phase Transition Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Spindle Pole Regulation Of Cell Cycle Acinar Cell Differentiation Synapse Organization Chromosome, Centromeric Region Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Microtubule Polymerization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Hematopoietic Or Lymphoid Organ Development Cell Division Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Trachea Formation PTW/PP1 Phosphatase Complex Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Cytoskeleton Cytosol Regulation Of Circadian Rhythm	Positive Regulation Of Cellular Component Organization Regulation Of Transport Leukocyte Migration Regulation Of D-glucose Transmembrane Transport Protein Kinase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Negative Regulation Of Neuron Differentiation Focal Adhesion Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Regulation Of Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Regulation Of Cellular Localization Regulation Of Vesicle-mediated Transport Cell Projection Morphogenesis Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Anoikis Regulation Of Endocytosis Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Regulation Of Anoikis Integrin Binding Perinuclear Region Of Cytoplasm Ionotropic Glutamate Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signaling Receptor Binding Establishment Or Maintenance Of Cell Polarity Cellular Response To Fluid Shear Stress Antigen Binding Plasma Membrane Fc-gamma Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Cellular Response To Peptide Hormone Stimulus Vesicle Cell Projection Positive Regulation Of Protein Localization Regulation Of Cellular Component Organization Developmental Maturation Positive Regulation Of Transport C5L2 Anaphylatoxin Chemotactic Receptor Binding Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Developmental Process P2Y1 Nucleotide Receptor Binding Adherens Junction
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