NEK2 and TCF25

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NEK2	TCF25
Gene Name		NIMA-related kinase 2	transcription factor 25 (basic helix-loop-helix)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleolus Cytoplasm Centrosome Cytosol Microtubule Midbody Protein Complex Intercellular Bridge	Nucleus
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Metal Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Organelle Organization Chromosome Segregation Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA Binding Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Heart Development
Pathways		Organelle biogenesis and maintenance APC/C:Cdc20 mediated degradation of mitotic proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: CCDC85A CEP250 CHGA CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PPP1CA PPP1CC PPP1R2 SPTBN4 TCF25 TPM3	8 interactors: APPBP2 CCDC155 DERL1 GPRASP2 MAGEA11 NEK2 RPS10 SAT1
Entrez ID		4751	22980
HPRD ID		04953	13830
Ensembl ID		ENSG00000117650	ENSG00000141002
Uniprot IDs		P51955	Q9BQ70
PDB IDs		2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Centriole-centriole Cohesion Glycogen Metabolic Process Mitotic Cell Cycle Polysaccharide Metabolic Process Regulation Of Organelle Organization Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Movement Of Cell Or Subcellular Component Cell Cycle Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Energy Reserve Metabolic Process Mitotic Cell Cycle Process Microtubule-based Process Cell Division Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA-directed RNA Polymerase Activity Regulation Of Metaphase Plate Congression Regulation Of Cytoskeleton Organization Cellular Protein Localization Cellular Carbohydrate Metabolic Process Centrosome Cycle Cellular Response To Growth Factor Stimulus MAPK Import Into Nucleus Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Response To Growth Factor Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chromosome Segregation Regulation Of Signal Transduction Cell Morphogenesis Circadian Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Response To Abiotic Stimulus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development Mitotic Nuclear Division Neuron Differentiation Establishment Of Organelle Localization	Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Centriole-centriole Cohesion Catabolic Process Spermidine Acetylation Establishment Of Localization In Cell Regulation Of Centriole-centriole Cohesion Putrescine Catabolic Process Cellular Macromolecule Catabolic Process Viral Life Cycle Intracellular Protein Transport Meiotic Cell Cycle Regulation Of Mitotic Centrosome Separation Oxalate Transport Intracellular Transport Of Viral Protein In Host Cell Retrograde Protein Transport, ER To Cytosol Chromosome Segregation Cellular Localization Polyamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Neurotransmitter Uptake Cellular Protein Localization Protein Transport Centrosome Separation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Establishment Of Protein Localization Polyamine Biosynthetic Process Intracellular Transport Mitotic Spindle Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore Amine Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Modification-dependent Protein Catabolic Process Intracellular Transport Of Virus Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Polyamine Metabolic Process Cellular Protein Catabolic Process Protein Localization Protein Catabolic Process Sulfate Transmembrane Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Establishment Of Chromosome Localization Sulfate Transport Mitotic Spindle Organization Negative Regulation Of DNA Binding Regulation Of Centrosome Cycle Neutral Amino Acid Transport
Tagcloud ?		called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 p45 proteasome proteolysis pull repeats seventh smc1 smc2 telophase
Tagcloud (Difference) ?		called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 p45 proteasome proteolysis pull repeats seventh smc1 smc2 telophase
Tagcloud (Intersection) ?