RNF213 and RPTOR

		RNF213	RPTOR
Description		ring finger protein 213	regulatory associated protein of MTOR complex 1
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GO Annotations	Cellular Component	Nucleolus Cytoplasm Lipid Droplet Cytosol Membrane	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Membrane Dendrite TORC1 Complex Neuronal Cell Body Serine/threonine Protein Kinase Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Protein-containing Complex Binding 14-3-3 Protein Binding Enzyme-substrate Adaptor Activity
	Biological Process	Angiogenesis Sprouting Angiogenesis Immune System Process Ubiquitin-dependent Protein Catabolic Process Lipid Metabolic Process Protein Ubiquitination Regulation Of Lipid Metabolic Process Defense Response To Bacterium Protein Autoubiquitination Protein K63-linked Ubiquitination Xenophagy Lipid Ubiquitination Lipid Droplet Formation Negative Regulation Of Non-canonical Wnt Signaling Pathway	Autophagosome Assembly Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Cytoplasmic Translation DNA Damage Response Regulation Of Cell Size Cellular Response To Starvation Response To Xenobiotic Stimulus Regulation Of Autophagy Negative Regulation Of Autophagy Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Social Behavior TORC1 Signaling Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Positive Regulation Of Lipid Biosynthetic Process Protein Localization To Lysosome Regulation Of Biological Quality Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Cellular Response To Glucose Stimulus Cellular Response To Hypoxia Cellular Response To Osmotic Stress Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Odontoblast Differentiation Positive Regulation Of TORC1 Signaling Positive Regulation Of Pentose-phosphate Shunt
Pathways		Suppression of apoptosis Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation	Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 33020668) Hypertension ( 32709000) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Migraine ( 27182965 27322543) Moyamoya disease ( 21048783 29273593)	Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)
Interacting Genes		17 interacting genes: GLUD1 GOLGA2 KRT40 MTDH PLAC9 REL SUMO2 TRIM23 TRIM27 TRIP6 UBC UBE2D2 UBE2D3 UBE2K UBE2L3 UBE2U UBXN11	27 interacting genes: CILK1 DUXAP9 EIF4EBP1 EIF4EBP2 GTF3C5 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NLK NRBF2 OGT PLD2 PPDPF PRKAA1 PRKAA2 RAP1B RHEB RPS6KA1 RPS6KA3 RPS6KB1 RRAGB WIPI2
Entrez ID		57674	57521
HPRD ID		10716	06184
Ensembl ID		ENSG00000173821	ENSG00000141564
Uniprot IDs		A0A0A0MTC1 A0A0A0MTR7 Q63HN8	Q8N122
PDB IDs		8S24	5H64 6BCU 6BCX 6SB0 6SB2 6U62 7OWG 7PEA 7PEB 7PEC 7UX2 7UXC 7UXH 8ERA 8RCH 8RCK 8RCN 9F42 9F43 9F44 9F45
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Macromolecule Catabolic Process Protein Tag Activity Proteolysis Negative Regulation Of Autophagy Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity SUMO Transferase Activity Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Catabolic Process Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Autophagy Macromolecule Metabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Type I Interferon Production Regulation Of Protein Targeting To Mitochondrion Nucleotide Binding Transferase Activity Positive Regulation Of Protein Metabolic Process Protein Sumoylation Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity ATP Binding Protein Autoubiquitination Transcription Coactivator Activity	TOR Signaling TORC1 Signaling Cellular Response To Nutrient Levels Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Translational Initiation Response To Nutrient Levels Intracellular Signal Transduction Regulation Of Translational Initiation Protein Serine Kinase Activity Insulin Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Regulation Of Translation Negative Regulation Of TOR Signaling Positive Regulation Of Translational Initiation Autophagosome Assembly Autophagosome Organization Negative Regulation Of Autophagy Cellular Response To Amino Acid Starvation Protein Kinase Activity Cellular Response To Starvation Negative Regulation Of Translation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Autophagy Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Lipid Metabolic Process Response To Starvation Post-transcriptional Regulation Of Gene Expression Kinase Activity Positive Regulation Of Small Molecule Metabolic Process Regulation Of Autophagy Negative Regulation Of Catabolic Process Vacuole Organization Regulation Of Glycolytic Process Organelle Assembly Positive Regulation Of Glycolytic Process Cytoplasmic Translation Positive Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Catabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of ATP Metabolic Process Nucleotide Binding Insulin-like Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Purine Nucleotide Metabolic Process
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