CIP2A and NDC80

Number of citations of the paper that reports this interaction (PubMedID 25833693)
0

Data Source:
BioGRID (two hybrid)

		CIP2A	NDC80
Description		cellular inhibitor of PP2A	NDC80 kinetochore complex component
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GO Annotations	Cellular Component	Chromosome Cytoplasm Centrosome Cytosol Plasma Membrane Ciliary Basal Body	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Membrane Nuclear Speck Ndc80 Complex
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Protein Homodimerization Activity Cadherin Binding	Protein Binding Microtubule Binding Cyclin Binding Identical Protein Binding Kinetochore Adaptor Activity
	Biological Process	DNA Damage Response Chromosome Organization Broken Chromosome Clustering	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Division Spindle Organization Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling G2/MI Transition Of Meiotic Cell Cycle Attachment Of Spindle Microtubules To Kinetochore Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Stability Chromosome Organization Centrosome Duplication Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Nuclear Chromosome Segregation
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		22 interacting genes: CDK1 CENPC CEP152 CEP192 CSPP1 GOLGA4 LAMB2 MYC NDC80 NEK2 PIK3R1 PPP2R5C PSMA1 PSMA3 RBM5 RNF2 SMC5 STUB1 SYNCRIP TOPBP1 UBR5 WWC3	57 interacting genes: AMOTL2 ATF4 ATP5PO ATP6V1D AURKA AURKB BLOC1S6 CAGE1 CALCOCO1 CCDC136 CCHCR1 CCNH CCNK CEP63 CIP2A CKAP5 EXOC8 GOLGA2 HAUS1 HGS IFT20 INPP1 KIFC3 KLC3 KLHL12 KRT27 KRT6B KRT75 LNX1 MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PPP1R13B PSMC2 RB1 SFR1 SKA1 SKA3 SMC1A SPC25 STX11 TFIP11 THOC7 TOM1L1 TXLNA USHBP1 VPS52 WASHC1 WASHC3 ZNF655 ZWINT
Entrez ID		57650	10403
HPRD ID		11151	06277
Ensembl ID		ENSG00000163507	ENSG00000080986
Uniprot IDs		Q8TCG1	A8K031 O14777
PDB IDs		5UFL	2IGP 2VE7 3IZ0 8G0P
Enriched GO Terms of Interacting Partners?		Nucleoplasm Chromosome Organization Centrosome Chromosome Chromosome, Centromeric Region Centrosome Duplication Procentriole DNA Damage Response Cytosol Positive Regulation Of Chromosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Import Into Nucleus Cytoplasm Microtubule Cytoskeleton Organization Involved In Mitosis Procentriole Replication Complex Chromosome Segregation Mitotic Cell Cycle Membraneless Organelle Assembly Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Process Proteasome Core Complex, Alpha-subunit Complex Cell Cycle Phase Transition Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Body Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Catabolic Process Microtubule Organizing Center Organization Ubiquitin-ubiquitin Ligase Activity Kinetochore Organization Positive Regulation Of Intracellular Protein Transport Proteolysis Involved In Protein Catabolic Process Mitotic Spindle Organization Spindle Assembly Cell Division Positive Regulation Of Protein Localization To Nucleus Attachment Of Mitotic Spindle Microtubules To Kinetochore Proteasome Core Complex DNA Metabolic Process Protein Localization To Chromosome Intracellular Signal Transduction Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cell Cycle Process Peptidyl-threonine Phosphorylation Macromolecule Metabolic Process Regulation Of Cell Cycle PML Body	Kinetochore Cell Division Chromosome, Centromeric Region Organelle Organization Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Spindle Organization Attachment Of Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Centrosome Regulation Of Chromosome Separation Negative Regulation Of Cell Cycle Process Nuclear Chromosome Segregation Microtubule-based Process Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Mitotic Sister Chromatid Segregation Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Sister Chromatid Segregation Regulation Of Sister Chromatid Segregation Spindle Pole Cytoskeleton Organization Regulation Of Chromosome Segregation Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Chromosome Spindle Regulation Of Chromosome Organization Positive Regulation Of Mitotic Sister Chromatid Separation Organelle Assembly Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Binding Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Cell Cycle Process Microtubule Chromosome Organization Membraneless Organelle Assembly Cytoskeleton Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cell Cycle
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