CIP2A and PPP2R5C

Number of citations of the paper that reports this interaction (PubMedID 28174209)
45

Data Source:
BioGRID (pull down)

		CIP2A	PPP2R5C
Description		cellular inhibitor of PP2A	protein phosphatase 2 regulatory subunit B'gamma
Image
GO Annotations	Cellular Component	Chromosome Cytoplasm Centrosome Cytosol Plasma Membrane Ciliary Basal Body	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Golgi Apparatus Cytosol
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Protein Homodimerization Activity Cadherin Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	DNA Damage Response Chromosome Organization Broken Chromosome Clustering	Signal Transduction Negative Regulation Of Cell Population Proliferation DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Meiotic Sister Chromatid Cohesion
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs			2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS			Anti-saccade response ( 29064472) Autism ( 20663923) Leukoderma in response to rhododendrol ( 32558222) Metabolite levels ( 23823483)
Interacting Genes		22 interacting genes: CDK1 CENPC CEP152 CEP192 CSPP1 GOLGA4 LAMB2 MYC NDC80 NEK2 PIK3R1 PPP2R5C PSMA1 PSMA3 RBM5 RNF2 SMC5 STUB1 SYNCRIP TOPBP1 UBR5 WWC3	21 interacting genes: APP ATM AXIN1 BRCA1 BUB1B CHEK2 CIP2A EP300 IER3 MAPK1 MBP OGT PAXIP1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1B PRKCD PXN SGO1
Entrez ID		57650	5527
HPRD ID		11151	03385
Ensembl ID		ENSG00000163507	ENSG00000078304
Uniprot IDs		Q8TCG1	A0A8Q3WKR3 Q13362
PDB IDs		5UFL	2IAE 2JAK 2NPP 2NYL 2NYM 3FGA 5JJA 5K6S 5SW9 5SWF 6OYL 6TOQ 6VOY 6VRO 7OUF 7OUG 7OUH 7PEL 7SOY
Enriched GO Terms of Interacting Partners?		Nucleoplasm Chromosome Organization Centrosome Chromosome Chromosome, Centromeric Region Centrosome Duplication Procentriole DNA Damage Response Cytosol Positive Regulation Of Chromosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Import Into Nucleus Cytoplasm Microtubule Cytoskeleton Organization Involved In Mitosis Procentriole Replication Complex Chromosome Segregation Mitotic Cell Cycle Membraneless Organelle Assembly Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Process Proteasome Core Complex, Alpha-subunit Complex Cell Cycle Phase Transition Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Body Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Catabolic Process Microtubule Organizing Center Organization Ubiquitin-ubiquitin Ligase Activity Kinetochore Organization Positive Regulation Of Intracellular Protein Transport Proteolysis Involved In Protein Catabolic Process Mitotic Spindle Organization Spindle Assembly Cell Division Positive Regulation Of Protein Localization To Nucleus Attachment Of Mitotic Spindle Microtubules To Kinetochore Proteasome Core Complex DNA Metabolic Process Protein Localization To Chromosome Intracellular Signal Transduction Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cell Cycle Process Peptidyl-threonine Phosphorylation Macromolecule Metabolic Process Regulation Of Cell Cycle PML Body	Response To Radiation Regulation Of Carbohydrate Catabolic Process Intracellular Signal Transduction Apoptotic Process Regulation Of Glycolytic Process Programmed Cell Death Regulation Of Small Molecule Metabolic Process Cell Death Regulation Of Generation Of Precursor Metabolites And Energy DNA Damage Response Regulation Of ATP Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Purine Nucleotide Metabolic Process PTW/PP1 Phosphatase Complex Intrinsic Apoptotic Signaling Pathway Regulation Of Organelle Organization Chromosome Cellular Response To Stress Chromosome Organization Protein Modification Process Regulation Of Cellular Response To Stress Regulation Of Cellular Component Organization Cytosol Circadian Rhythm Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Regulation Of Intracellular Transport Regulation Of Cell Cycle Phase Transition Cell Division Signal Transduction In Response To DNA Damage RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Circadian Regulation Of Gene Expression Mitotic DNA Damage Checkpoint Signaling Response To Lead Ion Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Radiation Positive Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Mitotic Cell Cycle Chromosome, Telomeric Region Regulation Of Cell Cycle Process Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Cellular Localization Organelle Organization Phosphate-containing Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Cycle Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity
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