CIP2A and LAMB2

Number of citations of the paper that reports this interaction (PubMedID 34145035)
49

Data Source:
BioGRID (two hybrid)

		CIP2A	LAMB2
Description		cellular inhibitor of PP2A	laminin subunit beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome Cytoplasm Centrosome Cytosol Plasma Membrane Ciliary Basal Body	Extracellular Region Basement Membrane Laminin-3 Complex Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction Synaptic Cleft Laminin Complex Laminin-11 Complex Synapse Extracellular Exosome Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Protein Homodimerization Activity Cadherin Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Structural Constituent Of Synapse-associated Extracellular Matrix
	Biological Process	DNA Damage Response Chromosome Organization Broken Chromosome Clustering	Cell Morphogenesis Cell Adhesion Axon Guidance Neuromuscular Junction Development Visual Perception Astrocyte Development Schwann Cell Development Neuron Projection Development Positive Regulation Of Cell Adhesion Axon Extension Involved In Regeneration Synapse Organization Positive Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Metanephric Podocyte Development Metanephric Glomerular Basement Membrane Development Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways			Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases			Pierson syndrome
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Myocardial infarction ( 33532862) PR interval ( 32439900) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		22 interacting genes: CDK1 CENPC CEP152 CEP192 CSPP1 GOLGA4 LAMB2 MYC NDC80 NEK2 PIK3R1 PPP2R5C PSMA1 PSMA3 RBM5 RNF2 SMC5 STUB1 SYNCRIP TOPBP1 UBR5 WWC3	12 interacting genes: ATXN7 CIP2A HOXA1 KPNA2 ORC5 PIK3R2 PLEKHA5 RBL1 STAT3 STIP1 TSR2 ZNF512B
Entrez ID		57650	3913
HPRD ID		11151	01034
Ensembl ID		ENSG00000163507	ENSG00000172037
Uniprot IDs		Q8TCG1	P55268
PDB IDs		5UFL
Enriched GO Terms of Interacting Partners?		Nucleoplasm Chromosome Organization Centrosome Chromosome Chromosome, Centromeric Region Centrosome Duplication Procentriole DNA Damage Response Cytosol Positive Regulation Of Chromosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Import Into Nucleus Cytoplasm Microtubule Cytoskeleton Organization Involved In Mitosis Procentriole Replication Complex Chromosome Segregation Mitotic Cell Cycle Membraneless Organelle Assembly Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Process Proteasome Core Complex, Alpha-subunit Complex Cell Cycle Phase Transition Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Body Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Catabolic Process Microtubule Organizing Center Organization Ubiquitin-ubiquitin Ligase Activity Kinetochore Organization Positive Regulation Of Intracellular Protein Transport Proteolysis Involved In Protein Catabolic Process Mitotic Spindle Organization Spindle Assembly Cell Division Positive Regulation Of Protein Localization To Nucleus Attachment Of Mitotic Spindle Microtubules To Kinetochore Proteasome Core Complex DNA Metabolic Process Protein Localization To Chromosome Intracellular Signal Transduction Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cell Cycle Process Peptidyl-threonine Phosphorylation Macromolecule Metabolic Process Regulation Of Cell Cycle PML Body
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