PTBP1 and TRAK1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PTBP1	TRAK1
Description		polypyrimidine tract binding protein 1	trafficking kinesin protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Endosome Early Endosome Cytosol Cell Cortex Membrane Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Axonal Growth Cone Perinuclear Region Of Cytoplasm Axon Cytoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Poly-pyrimidine Tract Binding Pre-mRNA Binding	Protein Binding Myosin Binding TPR Domain Binding GABA Receptor Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Neurogenesis Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Calcineurin-NFAT Signaling Cascade IRES-dependent Viral Translational Initiation Negative Regulation Of MRNA Metabolic Process	Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Protein Targeting Endosome To Lysosome Transport Axonal Transport Of Mitochondrion Neurogenesis Vesicle Transport Along Microtubule Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Axonogenesis
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Signaling by BRAF and RAF1 fusions RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Lymphocyte percentage of white cells ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Body mass index ( 28552196) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) PR interval ( 32439900) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		118 interacting genes: APBB1 APP CALCOCO2 CASP3 CCAT1 CEBPA FOXP1 FUS H3-4 HIF1A HMGA1 HMGA2 HNRNPAB HNRNPL HNRNPLL IL7R LIN28A LINC00624 LINC00839 LINC01554 MARK4 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NDUFV3 NONO OGT PCBP1 PCBP2 PCBP3 PKLR PRKACA PRPF40A QKI RAVER1 RAVER2 RBFOX2 RBM10 RNF10 SERPINB5 SFPQ SNCA SNRPA SRPK2 SUMO2 TRAK1 USP36 ZC3H8 ZMYM2	17 interacting genes: BLOC1S6 BYSL CDC5L CDK6 ENKD1 ESS2 HGS MAGEB4 OGT POLR2A PRPF6 PTBP1 SKIL SNW1 TRAF3IP1 UTP6 ZNF232
Entrez ID		5725	22906
HPRD ID		02823	09732
Ensembl ID		ENSG00000011304	ENSG00000182606
Uniprot IDs		A0A7I2V621 P26599	A0A087X0N0 A0A0D9SFL5 B7Z218 B7ZAE5 C9JC32 Q9UPV9
PDB IDs		1QM9 1SJQ 1SJR 2AD9 2ADB 2ADC 2EVZ 2N3O 3ZZY 3ZZZ 8BGF 8BWF
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process MRNA Destabilization Positive Regulation Of MRNA Catabolic Process RNA Destabilization Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cytokine Production Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of MRNA Stability Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Developmental Process Negative Regulation Of Cell Motility Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Locomotion Regulation Of MRNA Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration	Catalytic Step 2 Spliceosome RNA Processing RNA Metabolic Process Spliceosomal Complex RNA Splicing MRNA Metabolic Process Nucleoplasm MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Prp19 Complex Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Binding Blastocyst Formation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Dentate Gyrus Development Regulation Of Cellular Response To Growth Factor Stimulus U2-type Catalytic Step 2 Spliceosome Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organelle Assembly Maturation Of SSU-rRNA Regulation Of RNA Splicing Positive Regulation Of RNA Splicing Ciliary Base Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin D2-CDK6 Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle SMAD Binding Nucleus Regulation Of Macromolecule Metabolic Process Protein Domain Specific Binding Protein Localization To Lysosome Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding
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