PTBP1 and USP36

Number of citations of the paper that reports this interaction (PubMedID 35964538)
0

Data Source:
BioGRID (unspecified method)

		PTBP1	USP36
Description		polypyrimidine tract binding protein 1	ubiquitin specific peptidase 36
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Poly-pyrimidine Tract Binding Pre-mRNA Binding	RNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Transferase Activity Hydrolase Activity Histone H2B Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Neurogenesis Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Calcineurin-NFAT Signaling Cascade IRES-dependent Viral Translational Initiation Negative Regulation Of MRNA Metabolic Process	Chromatin Organization Chromatin Remodeling Proteolysis Nucleolus Organization Negative Regulation Of Macroautophagy Protein Deubiquitination Regulation Of Protein Stability Regulation Of Apoptotic Process Protein Stabilization Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of RRNA Processing
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Lymphocyte percentage of white cells ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Atrial fibrillation ( 30061737) Diverticular disease ( 30177863) Heel bone mineral density ( 30598549) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418 31928498)
Interacting Genes		118 interacting genes: APBB1 APP CALCOCO2 CASP3 CCAT1 CEBPA FOXP1 FUS H3-4 HIF1A HMGA1 HMGA2 HNRNPAB HNRNPL HNRNPLL IL7R LIN28A LINC00624 LINC00839 LINC01554 MARK4 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NDUFV3 NONO OGT PCBP1 PCBP2 PCBP3 PKLR PRKACA PRPF40A QKI RAVER1 RAVER2 RBFOX2 RBM10 RNF10 SERPINB5 SFPQ SNCA SNRPA SRPK2 SUMO2 TRAK1 USP36 ZC3H8 ZMYM2	19 interacting genes: ALKBH5 EXOSC10 H2BC3 MIR128-1 MIR138-2 MIR15B MIR16-1 MIR17 MIR19B2 MIR21 MIR29A MIR29C MIR34B MIR7-1 MYC PRIMPOL PTBP1 SUMO2 UBE2I
Entrez ID		5725	57602
HPRD ID		02823	07164
Ensembl ID		ENSG00000011304	ENSG00000055483
Uniprot IDs		A0A7I2V621 P26599	A0A075B784 Q9P275
PDB IDs		1QM9 1SJQ 1SJR 2AD9 2ADB 2ADC 2EVZ 2N3O 3ZZY 3ZZZ 8BGF 8BWF	8BS3 8BS9
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process MRNA Destabilization Positive Regulation Of MRNA Catabolic Process RNA Destabilization Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cytokine Production Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of MRNA Stability Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Developmental Process Negative Regulation Of Cell Motility Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Locomotion Regulation Of MRNA Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Regulation Of Translation Positive Regulation Of Connective Tissue Replacement Extracellular Vesicle Regulation Of Connective Tissue Replacement Regulation Of Gene Expression Positive Regulation Of Tissue Remodeling Regulation Of Macromolecule Biosynthetic Process Regulation Of Endothelial Cell Proliferation Negative Regulation Of Amyloid-beta Formation Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Developmental Process Regulation Of Amide Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition
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