TRAK1 and PRPF6

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		TRAK1	PRPF6
Description		trafficking kinesin protein 1	pre-mRNA processing factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endosome Early Endosome Cytosol Cell Cortex Membrane Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Axonal Growth Cone Perinuclear Region Of Cytoplasm Axon Cytoplasm	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Centrosome Cytosol Membrane Nuclear Speck Ciliary Basal Body U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Myosin Binding TPR Domain Binding GABA Receptor Binding	RNA Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Protein Targeting Endosome To Lysosome Transport Axonal Transport Of Mitochondrion Neurogenesis Vesicle Transport Along Microtubule Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Axonogenesis	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Localization RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Signaling by BRAF and RAF1 fusions RHOT2 GTPase cycle RHOT1 GTPase cycle	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Body mass index ( 28552196) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) PR interval ( 32439900) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Body mass index ( 28552196) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: BLOC1S6 BYSL CDC5L CDK6 ENKD1 ESS2 HGS MAGEB4 OGT POLR2A PRPF6 PTBP1 SKIL SNW1 TRAF3IP1 UTP6 ZNF232	67 interacting genes: AR ARAF BAG4 BICD2 C1orf35 CD2BP2 CEBPA CEP55 CLK2 CPSF7 CTBP1 CTTN DDX17 DMRTB1 EFTUD2 EHMT2 ESR1 EXOSC7 EXOSC8 FHIT FXR2 HNRNPLL HOOK1 IDH3A KIF24 KRT31 LARP4 LMNA MRPL1 MRPL44 MRPS11 NIN NME1 NR3C1 PCM1 PHF5A PPIE QKI RAF1 RBM22 RBPMS RNF10 RPL36AL RYBP SF3B4 SMARCA2 SNRNP200 SNRNP48 SNRNP70 SNRPA SNRPF SRRM2 SRSF2 SRSF8 SUMO2 SUN2 TFIP11 THOC1 TIMM44 TRAK1 TRMT1L TSNAXIP1 TXNL4B USO1 VIM YWHAB ZRSR2
Entrez ID		22906	24148
HPRD ID		09732	10729
Ensembl ID		ENSG00000182606	ENSG00000101161
Uniprot IDs		A0A087X0N0 A0A0D9SFL5 B7Z218 B7ZAE5 C9JC32 Q9UPV9	O94906
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		Catalytic Step 2 Spliceosome RNA Processing RNA Metabolic Process Spliceosomal Complex RNA Splicing MRNA Metabolic Process Nucleoplasm MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Prp19 Complex Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Binding Blastocyst Formation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Dentate Gyrus Development Regulation Of Cellular Response To Growth Factor Stimulus U2-type Catalytic Step 2 Spliceosome Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organelle Assembly Maturation Of SSU-rRNA Regulation Of RNA Splicing Positive Regulation Of RNA Splicing Ciliary Base Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin D2-CDK6 Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle SMAD Binding Nucleus Regulation Of Macromolecule Metabolic Process Protein Domain Specific Binding Protein Localization To Lysosome Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding	RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Metabolic Process Nucleic Acid Binding Nuclear Speck Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Nucleoplasm Regulation Of RNA Splicing U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Protein Binding Identical Protein Binding U2-type Catalytic Step 2 Spliceosome U5 SnRNP Ribonucleoprotein Complex Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Estrogen Response Element Binding Regulation Of MRNA Processing Microtubule Anchoring At Microtubule Organizing Center Spliceosomal Complex Assembly U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing U1 SnRNP Estrogen Receptor Signaling Pathway Regulation Of Primary Metabolic Process Microtubule Anchoring U2-type Prespliceosome Assembly Protein-RNA Complex Assembly Nuclear Migration Regulation Of Alternative MRNA Splicing, Via Spliceosome U2 SnRNP Nuclear Matrix Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process U2-type Spliceosomal Complex Steroid Hormone Receptor Signaling Pathway
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