TRAK1 and TRAF3IP1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		TRAK1	TRAF3IP1
Gene Name		trafficking protein, kinesin binding 1	TNF receptor-associated factor 3 interacting protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Early Endosome	Centrosome Cilium Axoneme Intraciliary Transport Particle B Ciliary Basal Body Primary Cilium Ciliary Tip
	Molecular Function	Protein Binding GABA Receptor Binding	Protein Binding Microtubule Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Protein O-linked Glycosylation Protein Targeting Endosome To Lysosome Transport	Organelle Organization Neural Tube Patterning Embryonic Camera-type Eye Development Negative Regulation Of Interferon-beta Production Embryonic Heart Tube Development Post-anal Tail Morphogenesis Intraciliary Transport Cilium Assembly Embryonic Digit Morphogenesis Negative Regulation Of Defense Response To Virus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways			Organelle biogenesis and maintenance Assembly of the primary cilium Intraflagellar transport
Drugs
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Iris characteristics ( 21835309)
Protein-Protein Interactions		7 interactors: CDC5L CDK6 HGS OGT POLR2A SKIL TRAF3IP1	27 interactors: ABI2 APP CCDC93 CCNA2 CDC5L DISC1 DMD DST DTNBP1 EXOC1 FRMD4A GOLGA4 IL13RA1 IMMT MACF1 OLFM1 SFR1 SMC2 SMC3 SMC4 SNAP91 SPTBN1 TAB2 TRAF3 TRAF6 TRAK1 WAC
Entrez ID		22906	26146
HPRD ID		09732	09571
Ensembl ID		ENSG00000182606	ENSG00000204104
Uniprot IDs		B7Z218 B7ZAE5 C9JC32 J3KNT7 Q9UPV9	Q8TDR0
PDB IDs			2EQO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Cell Dedifferentiation Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Transcription, RNA-templated Cell Cycle Arrest Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Negative Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Regulation Of Myeloid Cell Differentiation Regulation Of Cell Cycle DNA-templated Transcription, Initiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Granulocyte Differentiation Cellular Response To Stimulus Cell Cycle Process Negative Regulation Of Cellular Senescence Epithelium Development Negative Regulation Of Signal Transduction Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Stem Cell Differentiation Protein Targeting To Lysosome Protein Heterotrimerization Positive Regulation Of Histone H3-K27 Methylation Negative Regulation Of Signaling Histone H3-K4 Trimethylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Aging Negative Regulation Of Interferon-beta Production Regulation Of Histone H3-K27 Methylation Protein Localization To Lysosome RNA Splicing Histone H4-K16 Acetylation Camera-type Eye Development Positive Regulation Of Histone H3-K4 Methylation Regulation Of Signal Transduction Regulation Of Immune System Process Negative Regulation Of Immune System Process Regulation Of Metabolic Process Dentate Gyrus Development Cell Cycle Type B Pancreatic Cell Development Protein Homotrimerization	Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Cell Cycle Process Golgi To Plasma Membrane Protein Transport Meiotic Chromosome Condensation Cell Cycle Golgi Vesicle Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stress Generation Of Neurons TRIF-dependent Toll-like Receptor Signaling Pathway Neurogenesis Organelle Organization MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Signaling Cell Communication Mitotic Sister Chromatid Segregation Cell Division Establishment Of Protein Localization To Plasma Membrane Regulation Of Neurogenesis Toll-like Receptor 4 Signaling Pathway Nervous System Development Negative Regulation Of Cell Cycle Vesicle-mediated Transport Sister Chromatid Segregation Movement Of Cell Or Subcellular Component Cellular Localization Mitochondrial Calcium Ion Homeostasis Regulation Of Cell Differentiation Toll-like Receptor Signaling Pathway Membrane Organization Regulation Of Cell Development Regulation Of Neuron Differentiation Kinetochore Organization Mitotic Nuclear Division Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Metabolic Process Mitotic Chromosome Condensation Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Cycle Innate Immune Response-activating Signal Transduction Cellular Response To Stimulus Response To Stimulus Activation Of Innate Immune Response Signal Transduction Cell Differentiation Protein Localization To Plasma Membrane DNA Damage Checkpoint Regulation Of Neuron Projection Development
Tagcloud ?			13r1 arches chlamydomonas cilia ciliary ciliogenesis cilium connections cytoskeletal disc1 dyf elipsa enlarged evolutionarily hedgehog homologs ift54 localizes microtubules mipt3 patterning pharyngeal polydactyly raises sequestration stat6 tnfr ventral
Tagcloud (Difference) ?			13r1 arches chlamydomonas cilia ciliary ciliogenesis cilium connections cytoskeletal disc1 dyf elipsa enlarged evolutionarily hedgehog homologs ift54 localizes microtubules mipt3 patterning pharyngeal polydactyly raises sequestration stat6 tnfr ventral
Tagcloud (Intersection) ?