TRAK1 and CDK6

Number of citations of the paper that reports this interaction (PMID 22094256)
37

Data Source:
BioGRID (enzymatic study)

		TRAK1	CDK6
Gene Name		trafficking protein, kinesin binding 1	cyclin-dependent kinase 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Early Endosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding GABA Receptor Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Protein O-linked Glycosylation Protein Targeting Endosome To Lysosome Transport	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development T Cell Differentiation In Thymus Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Hematopoietic Stem Cell Differentiation Regulation Of Cell Motility Negative Regulation Of Cellular Senescence
Pathways			Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Height ( 20881960 19343178 23563607 18391950 18391951 18391952) Rheumatoid arthritis ( 18794853) White blood cell count ( 20139978 21738479) White blood cell types ( 21738478)
Protein-Protein Interactions		7 interactors: CDC5L CDK6 HGS OGT POLR2A SKIL TRAF3IP1	92 interactors: ABI2 ANKRD12 AR ATF6B ATXN1 BCL11A CASC3 CBY1 CCND1 CCND3 CDC37 CDC6 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DAB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 EZH2 FOXM1 FOXO3 HIST1H1A HSF1 ISL1 KIF26B KLF10 LPIN1 MCM10 MCM2 MEF2D MLLT3 MSL3 MYC MZF1 N4BP1 NFATC3 NIPBL NUMA1 PCNA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RB1 RBL1 RBL2 RBM23 RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 SYNPO2 TCEB3B TFDP1 TGFBR1 TJP2 TPX2 TRA2A TRA2B TRAK1 UHRF2 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1
Entrez ID		22906	1021
HPRD ID		09732	04533
Ensembl ID		ENSG00000182606	ENSG00000105810
Uniprot IDs		B7Z218 B7ZAE5 C9JC32 J3KNT7 Q9UPV9	A4D1G0 Q00534
PDB IDs			1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Cell Dedifferentiation Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Transcription, RNA-templated Cell Cycle Arrest Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Negative Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Regulation Of Myeloid Cell Differentiation Regulation Of Cell Cycle DNA-templated Transcription, Initiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Granulocyte Differentiation Cellular Response To Stimulus Cell Cycle Process Negative Regulation Of Cellular Senescence Epithelium Development Negative Regulation Of Signal Transduction Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Stem Cell Differentiation Protein Targeting To Lysosome Protein Heterotrimerization Positive Regulation Of Histone H3-K27 Methylation Negative Regulation Of Signaling Histone H3-K4 Trimethylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Aging Negative Regulation Of Interferon-beta Production Regulation Of Histone H3-K27 Methylation Protein Localization To Lysosome RNA Splicing Histone H4-K16 Acetylation Camera-type Eye Development Positive Regulation Of Histone H3-K4 Methylation Regulation Of Signal Transduction Regulation Of Immune System Process Negative Regulation Of Immune System Process Regulation Of Metabolic Process Dentate Gyrus Development Cell Cycle Type B Pancreatic Cell Development Protein Homotrimerization	RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cell Cycle Process Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process RNA Processing Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?			a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Difference) ?			a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Intersection) ?