TRAK1 and CDC5L

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		TRAK1	CDC5L
Gene Name		trafficking protein, kinesin binding 1	cell division cycle 5-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Early Endosome	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Nucleolus Cytoplasm Membrane Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding GABA Receptor Binding	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding WD40-repeat Domain Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Protein O-linked Glycosylation Protein Targeting Endosome To Lysosome Transport	MRNA Splicing, Via Spliceosome DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Splicing Gene Expression Signal Transduction Involved In DNA Damage Checkpoint
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Osteoarthritis ( 22763110) Stroke (ischemic) ( 22941190)
Protein-Protein Interactions		7 interactors: CDC5L CDK6 HGS OGT POLR2A SKIL TRAF3IP1	69 interactors: AKAP6 AKAP9 BCAS2 CALM1 CCDC136 CDK2 CDKN1A CDKN2A CDT1 CTNNBL1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GLTSCR1L GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HOOK1 KALRN KANSL1 KDM1A KIF3C KIF5B KRT18 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MYT1L ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF19 PRPF3 RPA1 RPA2 RPA3 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 TRAF3IP1 TRAK1 TRIO TTF2 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1
Entrez ID		22906	988
HPRD ID		09732	04184
Ensembl ID		ENSG00000182606	ENSG00000096401
Uniprot IDs		B7Z218 B7ZAE5 C9JC32 J3KNT7 Q9UPV9	Q99459
PDB IDs			2DIM 2DIN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Cell Dedifferentiation Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Transcription, RNA-templated Cell Cycle Arrest Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Negative Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Regulation Of Myeloid Cell Differentiation Regulation Of Cell Cycle DNA-templated Transcription, Initiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Granulocyte Differentiation Cellular Response To Stimulus Cell Cycle Process Negative Regulation Of Cellular Senescence Epithelium Development Negative Regulation Of Signal Transduction Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Stem Cell Differentiation Protein Targeting To Lysosome Protein Heterotrimerization Positive Regulation Of Histone H3-K27 Methylation Negative Regulation Of Signaling Histone H3-K4 Trimethylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Aging Negative Regulation Of Interferon-beta Production Regulation Of Histone H3-K27 Methylation Protein Localization To Lysosome RNA Splicing Histone H4-K16 Acetylation Camera-type Eye Development Positive Regulation Of Histone H3-K4 Methylation Regulation Of Signal Transduction Regulation Of Immune System Process Negative Regulation Of Immune System Process Regulation Of Metabolic Process Dentate Gyrus Development Cell Cycle Type B Pancreatic Cell Development Protein Homotrimerization	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation Organelle Organization Cellular Process DNA Recombinase Assembly Apoptotic Signaling Pathway DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Potassium Ion Transport Cellular Localization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Intracellular Signal Transduction Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Potassium Ion Transmembrane Transport G2/M Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Potassium Ion Transport Cellular Response To Heat Regulation Of Membrane Repolarization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition RNA Splicing Telomere Maintenance Via Recombination Nuclear DNA Replication Golgi To Plasma Membrane Protein Transport
Tagcloud ?			adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable
Tagcloud (Difference) ?			adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable
Tagcloud (Intersection) ?