TRPC7 and TRPC3

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		TRPC7	TRPC3
Name		transient receptor potential cation channel subfamily C member 7	transient receptor potential cation channel subfamily C member 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Plasma Membrane Membrane Cation Channel Complex Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Cation Channel Complex
	Molecular Function	Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding	Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Manganese Ion Transport Single Fertilization Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport	Monoatomic Ion Transport Calcium Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Response To ATP Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels
GWAS		Body fat percentage ( 31752434 ) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689 ) Interleukin-6 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683 ) Sleep duration (short sleep) ( 30846698 )	Asthma ( 31959851 34103634 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Emphysema imaging phenotypes ( 26030696 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Rosacea symptom severity ( 29771307 )
Interacting Genes		4 interacting genes: ITPR3 MX1 TRPC3 TRPC6	21 interacting genes: CALM1 FKBP1A FNDC5 GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		57113	7222
HPRD ID		18228	15999
Ensembl ID		ENSG00000069018	ENSG00000138741
Uniprot IDs		Q70T25 Q9HCX4	Q13507
PDB IDs		Not available	5ZBG 6CUD 6D7L 6DJS 7DXB 7DXC 7DXD 7DXE
GO Terms Enriched among Interactors		Inositol 1,4,5 Trisphosphate Binding Calcium Channel Activity Store-operated Calcium Channel Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Monoatomic Ion Channel Activity Calcium Ion Transmembrane Transport Cation Channel Complex Calcium Ion Homeostasis Calcium Ion Transport Inorganic Ion Homeostasis Regulation Of Cytosolic Calcium Ion Concentration Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Calcium Ion Transport Single Fertilization Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Response To Calcium Ion Fertilization Chemical Homeostasis Monoatomic Ion Transport Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Inositol Hexakisphosphate Binding Intracellular Calcium Ion Homeostasis Positive Regulation Of Monoatomic Ion Transport Sensory Perception Of Umami Taste Sensory Perception Of Sweet Taste Regulation Of Calcium Ion Transport Transmembrane Transport Inositol 1,3,4,5 Tetrakisphosphate Binding Sensory Perception Of Bitter Taste Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Homeostatic Process Regulation Of Monoatomic Ion Transmembrane Transport Interleukin-27-mediated Signaling Pathway Slit Diaphragm Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Negative Regulation Of Dendrite Morphogenesis Response To Metal Ion Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Metal Ion Transport Calcium-activated Cation Channel Activity Response To Type I Interferon Positive Regulation Of Calcium Ion Transport Into Cytosol	Regulation Of Sequestering Of Calcium Ion Calcium Ion Transmembrane Transport Calcium Ion Transport Metal Ion Transport Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Phosphatidylinositol Phospholipase C Activity Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Ion Transport Inorganic Ion Transmembrane Transport Store-operated Calcium Channel Activity Monoatomic Ion Transmembrane Transport Calcium Channel Activity Calcium-mediated Signaling Phospholipase C Activity Regulation Of Metal Ion Transport Regulation Of Transport Regulation Of Calcium Ion Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Insulin Secretion Plasma Membrane Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Calcium Ion Homeostasis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Positive Regulation Of Transport Calcium Ion Binding Phosphoric Diester Hydrolase Activity Intracellular Signaling Cassette Positive Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Protein Localization Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion