TRPC7 and TRPC3

Number of citations of the paper that reports this interaction (PMID 12032305)
131

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TRPC7	TRPC3
Gene Name		transient receptor potential cation channel, subfamily C, member 7	transient receptor potential cation channel, subfamily C, member 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cis-Golgi Network Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Calcium Channel Activity Protein Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Manganese Ion Transport Axon Guidance Blood Coagulation Platelet Activation Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport	Calcium Ion Transport Axon Guidance Blood Coagulation Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling	G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ITPR3 MX1 TRPC3 TRPC6	20 interactors: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		57113	7222
HPRD ID		18228	15999
Ensembl ID		ENSG00000069018	ENSG00000138741
Uniprot IDs		Q9HCX4	J3QTB0 Q13507
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Calcium Ion Transmembrane Transport Calcium Ion Transport Blood Coagulation Hemostasis Response To Inorganic Substance Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Calcium Ion Transport Cell Activation Response To Wounding Response To Calcium Ion Metal Ion Transport Cation Transmembrane Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Response To Stress Cation Transport Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Calcium Ion Homeostasis Sensory Perception Of Sweet Taste Calcium Ion Homeostasis Sensory Perception Of Umami Taste Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Response To Metal Ion Transmembrane Transport Axon Guidance Ion Transport Response To External Stimulus Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Axonogenesis Inositol Phosphate-mediated Signaling Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Chemical Homeostasis Ion Homeostasis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Ion Transport Neuron Projection Morphogenesis Response To ATP Response To Organic Substance Cellular Homeostasis Regulation Of Cardiac Muscle Hypertrophy	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Wound Healing Response To Wounding Activation Of Phospholipase C Activity Calcium Ion Transmembrane Transport Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Cell Activation Regulation Of Phospholipase Activity Calcium Ion Transport Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Platelet Activation Inositol Phosphate Metabolic Process Second-messenger-mediated Signaling Cellular Calcium Ion Homeostasis Regulation Of Ion Homeostasis Calcium Ion Homeostasis Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Synaptic Transmission Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Metal Ion Homeostasis Energy Reserve Metabolic Process Cellular Chemical Homeostasis Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Metal Ion Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Ion Homeostasis Chemical Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Signaling Response To Stimulus Cation Transmembrane Transport Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ion Transport Response To Fibroblast Growth Factor Regulation Of Calcium Ion Transport Into Cytosol
Tagcloud ?		21q22 affective bipolar c05c12 caenorhabditis caudate cdna consists constitute d21s171 d21s400 deafness elegans exons f54d1 hereditary holoprosencephaly hypothetical kb knobloch libraries mapped mentioned nonsyndromic northern noti spanning t01h8	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Difference) ?		21q22 affective bipolar c05c12 caenorhabditis caudate cdna consists constitute d21s171 d21s400 deafness elegans exons f54d1 hereditary holoprosencephaly hypothetical kb knobloch libraries mapped mentioned nonsyndromic northern noti spanning t01h8	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Intersection) ?