TRPC7 and TRPC6

Number of citations of the paper that reports this interaction (PubMedID 12032305)
37

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TRPC7	TRPC6
Description		transient receptor potential cation channel subfamily C member 7	transient receptor potential cation channel subfamily C member 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Plasma Membrane Membrane Cation Channel Complex Perinuclear Region Of Cytoplasm	Cytoplasm Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm
	Molecular Function	Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding	Actin Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Manganese Ion Transport Single Fertilization Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport	Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Monoatomic Ion Transmembrane Transport Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Body fat percentage ( 31752434) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) Interleukin-6 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Sleep duration (short sleep) ( 30846698)	Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Daytime nap ( 33568662) DHEAS levels ( 34748635) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 25231870) Monocyte count ( 32888494) Plateletcrit ( 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: ITPR3 MX1 TRPC3 TRPC6	9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2
Entrez ID		57113	7225
HPRD ID		18228	04710
Ensembl ID		ENSG00000069018	ENSG00000137672
Uniprot IDs		Q70T25 Q9HCX4	Q9Y210
PDB IDs			5YX9 6UZ8 6UZA 7A6U 7DXF 7DXG
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Calcium Channel Activity Store-operated Calcium Channel Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Monoatomic Ion Channel Activity Calcium Ion Transmembrane Transport Cation Channel Complex Calcium Ion Homeostasis Calcium Ion Transport Inorganic Ion Homeostasis Regulation Of Cytosolic Calcium Ion Concentration Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Calcium Ion Transport Single Fertilization Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Response To Calcium Ion Fertilization Chemical Homeostasis Monoatomic Ion Transport Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Inositol Hexakisphosphate Binding Intracellular Calcium Ion Homeostasis Positive Regulation Of Monoatomic Ion Transport Sensory Perception Of Umami Taste Sensory Perception Of Sweet Taste Regulation Of Calcium Ion Transport Transmembrane Transport Inositol 1,3,4,5 Tetrakisphosphate Binding Sensory Perception Of Bitter Taste Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Homeostatic Process Regulation Of Monoatomic Ion Transmembrane Transport Interleukin-27-mediated Signaling Pathway Slit Diaphragm Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Negative Regulation Of Dendrite Morphogenesis Response To Metal Ion Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Metal Ion Transport Calcium-activated Cation Channel Activity Response To Type I Interferon Positive Regulation Of Calcium Ion Transport Into Cytosol	Calcium Ion Transport Calcium Channel Activity Store-operated Calcium Channel Activity Calcium Ion Transmembrane Transport Inositol 1,4,5 Trisphosphate Binding Metal Ion Transport Monoatomic Cation Transport Monoatomic Ion Channel Activity Monoatomic Ion Transport Cellular Response To Hydrogen Peroxide Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Intracellularly Gated Calcium Channel Activity Inorganic Ion Transmembrane Transport Phospholipase Activator Activity Response To Hydrogen Peroxide Manganese Ion Transport Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Cation Channel Complex Response To Calcium Ion Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Response To Reactive Oxygen Species Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Calcium-mediated Signaling Ephrin Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Transmembrane Transport Membrane Raft Plasma Membrane Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Oxidative Stress Fc-gamma Receptor Signaling Pathway Calcium Ion Homeostasis Calcium Ion Import Regulation Of Calcium Ion Transport Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Homeostatic Process Membrane T Cell Costimulation Ephrin Receptor Signaling Pathway Cellular Response To Chemical Stress Perinuclear Region Of Cytoplasm Peptidyl-tyrosine Phosphorylation
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