TRPC7 and TRPC6

Number of citations of the paper that reports this interaction (PMID 12032305)
131

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TRPC7	TRPC6
Gene Name		transient receptor potential cation channel, subfamily C, member 7	transient receptor potential cation channel, subfamily C, member 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cis-Golgi Network Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Membrane Slit Diaphragm
	Molecular Function	Calcium Channel Activity Protein Binding	Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Manganese Ion Transport Axon Guidance Blood Coagulation Platelet Activation Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport	Cation Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Aging Blood Coagulation Platelet Activation Positive Regulation Of Ion Transmembrane Transporter Activity Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia
Pathways		G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling	G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ITPR3 MX1 TRPC3 TRPC6	9 interactors: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2
Entrez ID		57113	7225
HPRD ID		18228	04710
Ensembl ID		ENSG00000069018	ENSG00000137672
Uniprot IDs		Q9HCX4	Q9Y210
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Calcium Ion Transmembrane Transport Calcium Ion Transport Blood Coagulation Hemostasis Response To Inorganic Substance Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Calcium Ion Transport Cell Activation Response To Wounding Response To Calcium Ion Metal Ion Transport Cation Transmembrane Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Response To Stress Cation Transport Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Calcium Ion Homeostasis Sensory Perception Of Sweet Taste Calcium Ion Homeostasis Sensory Perception Of Umami Taste Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Response To Metal Ion Transmembrane Transport Axon Guidance Ion Transport Response To External Stimulus Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Axonogenesis Inositol Phosphate-mediated Signaling Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Chemical Homeostasis Ion Homeostasis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Ion Transport Neuron Projection Morphogenesis Response To ATP Response To Organic Substance Cellular Homeostasis Regulation Of Cardiac Muscle Hypertrophy	Calcium Ion Transport Blood Coagulation Hemostasis Platelet Activation Calcium Ion Transmembrane Transport Regulation Of Body Fluid Levels Wound Healing Response To Wounding Metal Ion Transport Response To Stress Cation Transport Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ion Transport Manganese Ion Transmembrane Transport Cation Transmembrane Transport Axon Guidance Manganese Ion Transport Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Axonogenesis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ion Transmembrane Transport Response To Hydroperoxide Chemotaxis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neuron Projection Morphogenesis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cell Morphogenesis Involved In Differentiation Phagocytosis Peptidyl-tyrosine Autophosphorylation Fc Receptor Signaling Pathway Innate Immune Response Neuron Projection Development Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Morphogenesis Transmembrane Transport Cell Part Morphogenesis Transport Response To External Stimulus Neuron Development
Tagcloud ?		21q22 affective bipolar c05c12 caenorhabditis caudate cdna consists constitute d21s171 d21s400 deafness elegans exons f54d1 hereditary holoprosencephaly hypothetical kb knobloch libraries mapped mentioned nonsyndromic northern noti spanning t01h8	blocker ca casr channels depending elicited eliminated exchanger expressions ip3 lymphocytes nicl2 nps plc rise sensing sepsis septic skf96365 sr stores tg thapsigargin transient trpc3 u73122 verapamil
Tagcloud (Difference) ?		21q22 affective bipolar c05c12 caenorhabditis caudate cdna consists constitute d21s171 d21s400 deafness elegans exons f54d1 hereditary holoprosencephaly hypothetical kb knobloch libraries mapped mentioned nonsyndromic northern noti spanning t01h8	blocker ca casr channels depending elicited eliminated exchanger expressions ip3 lymphocytes nicl2 nps plc rise sensing sepsis septic skf96365 sr stores tg thapsigargin transient trpc3 u73122 verapamil
Tagcloud (Intersection) ?