PNPLA2 and SERPINF1

Number of citations of the paper that reports this interaction (PMID 17032652)
55

Data Source:
BioGRID (pull down, pull down)

		PNPLA2	SERPINF1
Gene Name		patatin-like phospholipase domain containing 2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Lipid Particle Cytosol Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Melanosome Axon Hillock Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Triglyceride Lipase Activity	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Phospholipid Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Particle Organization Acylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process	Kidney Development Multicellular Organismal Development Aging Short-term Memory Cell Proliferation Response To Acidic PH Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Endopeptidase Activity Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Ovulation Cycle Response To Arsenic-containing Substance Negative Regulation Of Inflammatory Response Positive Regulation Of Neurogenesis Retina Development In Camera-type Eye Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Cobalt Ion Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Negative Regulation Of Neuron Death
Pathways		Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS			Calcium levels ( 20705733)
Protein-Protein Interactions		10 interactors: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2	7 interactors: CSNK2A1 EPM2AIP1 LRP6 MLH1 MYOC NEDD4L PNPLA2
Entrez ID		57104	5176
HPRD ID		11443	01408
Ensembl ID		ENSG00000177666	ENSG00000132386
Uniprot IDs		Q96AD5	P36955
PDB IDs			1IMV
Enriched GO Terms of Interacting Partners?		Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Post-Golgi Vesicle-mediated Transport Cellular Response To Cobalt Ion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Catalytic Activity Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Triglyceride Catabolic Process Regulation Of GTPase Activity Mullerian Duct Regression Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Receptor Recycling Response To Cobalt Ion Golgi Vesicle Transport Short-term Memory COPI-coated Vesicle Budding Positive Regulation Of Lipoprotein Lipase Activity COPI Coating Of Golgi Vesicle Positive Regulation Of Metabolic Process	Regulation Of Membrane Depolarization Wnt Signaling Pathway Regulation Of Cell Junction Assembly Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Skeletal Muscle Hypertrophy Meiotic Metaphase I Plate Congression ERBB2-ERBB3 Signaling Pathway Meiotic Spindle Midzone Assembly Regulation Of Metabolic Process External Genitalia Morphogenesis Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Negative Regulation Of Mitotic Recombination Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure ERBB2 Signaling Pathway Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Positive Regulation Of Caveolin-mediated Endocytosis Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Regulation Of Ion Homeostasis Cell Development Positive Regulation Of Metabolic Process Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Axis Elongation Involved In Somitogenesis Neural Crest Formation Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Glial Cell Differentiation Positive Regulation Of Glycogen (starch) Synthase Activity Mammary Placode Formation Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Acylglycerol Acyl-chain Remodeling Pericardium Morphogenesis Forebrain Radial Glial Cell Differentiation Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Non-canonical Wnt Signaling Pathway Via JNK Cascade Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Bone Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Wnt Signaling Pathway Involved In Somitogenesis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Negative Regulation Of Sodium Ion Transmembrane Transport
Tagcloud ?		abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated	cel coexpressions colocalization cyst cysts die exhaustively glycoproteins lac lipase lysozyme m1 mapping mining muc6 mucin mucinous multilectin nano nonglycoproteins nonmucinous novoseek ontology periostin pigment proteomic pyruvate quantitation ywhae
Tagcloud (Difference) ?		abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated	cel coexpressions colocalization cyst cysts die exhaustively glycoproteins lac lipase lysozyme m1 mapping mining muc6 mucin mucinous multilectin nano nonglycoproteins nonmucinous novoseek ontology periostin pigment proteomic pyruvate quantitation ywhae
Tagcloud (Intersection) ?