PNPLA2 and ARFGEF2

Number of citations of the paper that reports this interaction (PMID 21789191)
8

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PNPLA2	ARFGEF2
Gene Name		patatin-like phospholipase domain containing 2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Lipid Particle Cytosol Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Golgi Membrane Trans-Golgi Network Microtubule Organizing Center Cytosol Axonemal Microtubule Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Dendritic Spine Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Triglyceride Lipase Activity	Guanyl-nucleotide Exchange Factor Activity ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Phospholipid Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Particle Organization Acylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Metabolism of lipids and lipoproteins Acyl chain remodeling of DAG and TAG Phospholipid metabolism Glycerophospholipid biosynthesis	Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2	9 interactors: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 PNPLA2 PRKAR1A PRKAR2A PRPF40A
Entrez ID		57104	10564
HPRD ID		11443	09250
Ensembl ID		ENSG00000177666	ENSG00000124198
Uniprot IDs		Q96AD5	Q59FR3 Q86TH5 Q9Y6D5
PDB IDs			3L8N 3SWV
Enriched GO Terms of Interacting Partners?		Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Post-Golgi Vesicle-mediated Transport Cellular Response To Cobalt Ion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Catalytic Activity Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Triglyceride Catabolic Process Regulation Of GTPase Activity Mullerian Duct Regression Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Receptor Recycling Response To Cobalt Ion Golgi Vesicle Transport Short-term Memory COPI-coated Vesicle Budding Positive Regulation Of Lipoprotein Lipase Activity COPI Coating Of Golgi Vesicle Positive Regulation Of Metabolic Process	Cellular Response To Histamine Response To Histamine Cellular Response To Ammonium Ion Cellular Response To Organonitrogen Compound Negative Regulation Of CAMP-dependent Protein Kinase Activity Response To Ammonium Ion Response To Organonitrogen Compound Chloride Transmembrane Transport Regulation Of CAMP-dependent Protein Kinase Activity Activation Of Protein Kinase A Activity Chloride Transport Renal Water Homeostasis Innervation Cellular Response To Glucagon Stimulus Inner Ear Receptor Cell Development Inorganic Anion Transport Water Transport Fluid Transport Cochlea Development Activation Of Phospholipase C Activity Multicellular Organismal Water Homeostasis Response To Glucagon Positive Regulation Of Phospholipase C Activity Transmembrane Transport Inner Ear Receptor Cell Differentiation Water Homeostasis Mechanoreceptor Differentiation Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Positive Regulation Of Phospholipase Activity Anion Transmembrane Transport Positive Regulation Of Protein Glycosylation In Golgi Transport Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Nerve Development Renal System Process Synaptic Transmission Negative Regulation Of Protein Serine/threonine Kinase Activity Response To Organic Substance Energy Reserve Metabolic Process Positive Regulation Of Protein Glycosylation Sensory Perception Of Sound Anion Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Acylglycerol Acyl-chain Remodeling Negative Regulation Of Neuron Apoptotic Process Sensory Perception Of Mechanical Stimulus
Tagcloud ?		abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated	13q33 15q26 20q13 22q11 already c20orf199 candidate chromosomes copy cse1l ddx27 deficiency duplications gh hemizygous homozygous individuals integrin investigations itgbl1 kcnb1 mb oligonucleotide predispose ptgis remaining snord12 unreported znfx1
Tagcloud (Difference) ?		abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated	13q33 15q26 20q13 22q11 already c20orf199 candidate chromosomes copy cse1l ddx27 deficiency duplications gh hemizygous homozygous individuals integrin investigations itgbl1 kcnb1 mb oligonucleotide predispose ptgis remaining snord12 unreported znfx1
Tagcloud (Intersection) ?