PNPLA2

Description		patatin like domain 2, triacylglycerol lipase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane
	Molecular Function	Lipoprotein Lipase Activity Phospholipase A2 Activity Triacylglycerol Lipase Activity Protein Binding Acylglycerol O-acyltransferase Activity Hydrolase Activity Retinyl-palmitate Esterase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Acylglycerol Metabolic Process Diacylglycerol Biosynthetic Process Phototransduction, Visible Light Negative Regulation Of Triglyceride Storage Positive Regulation Of Triglyceride Catabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Intracellular Triglyceride Homeostasis Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Lipid Homeostasis Lipid Droplet Fusion Lipid Droplet Disassembly
Pathways		Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Keratoconus ( 31855235) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		57104
HPRD ID		11443
Ensembl ID		ENSG00000177666
Uniprot IDs		Q96AD5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of ARF Protein Signal Transduction Endomembrane System Organization Lipid Droplet Guanyl-nucleotide Exchange Factor Activity Protein Localization To Endoplasmic Reticulum Tubular Network Regulation Of Small GTPase Mediated Signal Transduction
Tagcloud ?