LXN and SPAG7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LXN	SPAG7
Description		latexin	sperm associated antigen 7
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Nucleus
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Heparin Binding Peptidase Inhibitor Activity	Nucleic Acid Binding Protein Binding
	Biological Process	Inflammatory Response Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Pathways
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)	Keratoconus ( 33649486) Mean platelet volume ( 27863252) Serum metabolite levels ( 33031748)
Interacting Genes		25 interacting genes: BOC CA3 COX6A1 CYBC1 DNAJC11 DPYD FCGR3A GSG1L IGSF11 MAGEA8 MCMDC2 NSMF PAX6 PPP1R3C RNF4 SHKBP1 SPAG7 TMEM14A TRAIP TRIM39 YIF1B ZCCHC17 ZKSCAN4 ZNF430 ZNF679	2 interacting genes: ABHD16A LXN
Entrez ID		56925	9552
HPRD ID		14327	10247
Ensembl ID		ENSG00000079257	ENSG00000091640
Uniprot IDs		Q9BS40	O75391
PDB IDs		2BO9	2CPM
Enriched GO Terms of Interacting Partners?			3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Organophosphate Catabolic Process Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Cellular Response To CGMP 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP Metabolic Process Cyclic Nucleotide Catabolic Process Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Macrophage Colony-stimulating Factor Negative Regulation Of CGMP-mediated Signaling 3',5'-cyclic-GMP Phosphodiesterase Activity Phosphate Ion Binding Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus CAMP Binding CGMP Catabolic Process TPR Domain Binding Regulation Of CGMP-mediated Signaling Monocyte Differentiation 3',5'-cyclic-nucleotide Phosphodiesterase Activity Response To 2,3,7,8-tetrachlorodibenzodioxine CGMP Binding Positive Regulation Of Vascular Permeability Negative Regulation Of Vascular Permeability Response To CGMP Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Monoacylglycerol Lipase Activity Phosphatidylserine Metabolic Process Monoacylglycerol Catabolic Process Phosphatidylcholine Lysophospholipase Activity Metalloendopeptidase Inhibitor Activity Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Temperature Stimulus Involved In Sensory Perception Heart Valve Development Glycerophospholipid Catabolic Process Detection Of Temperature Stimulus Negative Regulation Of CAMP/PKA Signal Transduction Phospholipase Activity Acylglycerol Catabolic Process CGMP-mediated Signaling Modified Amino Acid Catabolic Process Aorta Development Ventricular Septum Development Establishment Of Endothelial Barrier Cyclic Purine Nucleotide Metabolic Process Organophosphate Metabolic Process Artery Development Cardiac Septum Development
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