LXN and COX6A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LXN	COX6A1
Description		latexin	cytochrome c oxidase subunit 6A1
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Heparin Binding Peptidase Inhibitor Activity	Protein Binding Oxidoreductase Activity Enzyme Regulator Activity
	Biological Process	Inflammatory Response Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain	Generation Of Precursor Metabolites And Energy Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration
Pathways			TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)	Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		25 interacting genes: BOC CA3 COX6A1 CYBC1 DNAJC11 DPYD FCGR3A GSG1L IGSF11 MAGEA8 MCMDC2 NSMF PAX6 PPP1R3C RNF4 SHKBP1 SPAG7 TMEM14A TRAIP TRIM39 YIF1B ZCCHC17 ZKSCAN4 ZNF430 ZNF679	2 interacting genes: GRB2 LXN
Entrez ID		56925	1337
HPRD ID		14327	03644
Ensembl ID		ENSG00000079257	ENSG00000111775
Uniprot IDs		Q9BS40	H6SG15 P12074
PDB IDs		2BO9	5Z62
Enriched GO Terms of Interacting Partners?			Guanyl-nucleotide Exchange Factor Adaptor Activity Grb2-EGFR Complex Epidermal Growth Factor Receptor Binding Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity COP9 Signalosome Schwann Cell Development Endodermal Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Insulin-like Growth Factor Receptor Signaling Pathway Insulin Receptor Substrate Binding Ephrin Receptor Binding Vesicle Membrane Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Neurotrophin TRKA Receptor Binding Metalloendopeptidase Inhibitor Activity Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Phosphotyrosine Residue Binding Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity T Cell Costimulation Positive Regulation Of Actin Filament Polymerization Defense Response Regulation Of Natural Killer Cell Mediated Cytotoxicity B Cell Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Immunity Receptor Internalization Positive Regulation Of Reactive Oxygen Species Metabolic Process ERBB Signaling Pathway Glial Cell Development Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Ionizing Radiation Insulin Receptor Signaling Pathway Leukocyte Mediated Cytotoxicity Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Enzyme Inhibitor Activity Positive Regulation Of Protein Polymerization Protein Phosphatase Binding Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Myelination Axon Ensheathment
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