LXN and SHKBP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LXN	SHKBP1
Description		latexin	SH3KBP1 binding protein 1
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Lysosome
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Heparin Binding Peptidase Inhibitor Activity	Protein Binding Identical Protein Binding
	Biological Process	Inflammatory Response Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain	Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Homooligomerization
Pathways			CDC42 GTPase cycle
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)	Carotid intima media thickness (mean) ( 31801372) Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Hemoglobin levels ( 32327693)
Interacting Genes		25 interacting genes: BOC CA3 COX6A1 CYBC1 DNAJC11 DPYD FCGR3A GSG1L IGSF11 MAGEA8 MCMDC2 NSMF PAX6 PPP1R3C RNF4 SHKBP1 SPAG7 TMEM14A TRAIP TRIM39 YIF1B ZCCHC17 ZKSCAN4 ZNF430 ZNF679	14 interacting genes: CCNG1 COL7A1 CUL3 GRB2 HSP90AA1 HSP90AB1 LXN NR3C1 PIN1 PRPF3 SH3KBP1 UBC WEE2-AS1 YWHAG
Entrez ID		56925	92799
HPRD ID		14327	15338
Ensembl ID		ENSG00000079257	ENSG00000160410
Uniprot IDs		Q9BS40	Q8TBC3
PDB IDs		2BO9	4CRH
Enriched GO Terms of Interacting Partners?			Regulation Of Protein Modification Process Regulation Of Protein Stability Ubiquitin Protein Ligase Binding Tau Protein Binding Telomerase Holoenzyme Complex Assembly Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Protein-RNA Complex Assembly Protein Stabilization RNA Binding Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Identical Protein Binding Response To Temperature Stimulus Telomere Maintenance Via Telomere Lengthening Protein-containing Complex Assembly Protein Folding Chaperone Complex COP9 Signalosome Regulation Of Biological Quality ATP-dependent Protein Folding Chaperone Endodermal Cell Differentiation Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Ubiquitination Positive Regulation Of Nitric Oxide Metabolic Process Protein-containing Complex Organization Supramolecular Fiber Organization Regulation Of Protein Metabolic Process Collagen Type VII Trimer Guanyl-nucleotide Exchange Factor Adaptor Activity Nuclear Glucocorticoid Receptor Activity CTP Binding DATP Binding Cellular Response To Heat Cis-trans Isomerase Activity Cellular Response To Stress Regulation Of Post-translational Protein Modification Protein Folding Chaperone Nucleoplasm Response To Stress Response To Hormone Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation
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