TRIM8 and RNF7

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		TRIM8	RNF7
Gene Name		tripartite motif containing 8	ring finger protein 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol PML Body Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Zinc Ion Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity	Copper Ion Binding Protein Binding Zinc Ion Binding NEDD8 Transferase Activity Cullin Family Protein Binding
	Biological Process	Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Viral Release From Host Cell	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Protein Ubiquitination Negative Regulation Of Apoptotic Process Protein Neddylation Response To Redox State
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Hepatitis C induced liver fibrosis ( 22841784)
Protein-Protein Interactions		45 interactors: BRAP CBL CCNH ITSN1 MAP3K7 MKRN3 MSL2 OTUB2 PCGF5 RAD18 RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF181 RNF41 RNF7 SIAH1 SOCS1 TNFAIP3 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UHRF2 USP2 USP21 USP39 USP7 XIAP	34 interactors: ASB2 CASP7 CBFB CDC34 CHFR CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CYCS GEM GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L NFKBIA PLA2G15 TCEB1 TCEB2 TRIM46 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2F UBE2M UBE2Q1
Entrez ID		81603	9616
HPRD ID		06934	04840
Ensembl ID		ENSG00000171206
Uniprot IDs		Q9BZR9	Q9UBF6
PDB IDs			2ECL
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Protein Deubiquitination Negative Regulation Of Type I Interferon Production Immune Response Toll-like Receptor Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Protein Modification By Small Protein Removal Regulation Of Metabolic Process Negative Regulation Of Viral Release From Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K48-linked Deubiquitination Regulation Of Gene Expression Protein K63-linked Deubiquitination Cellular Process Regulation Of Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway	Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Viral Process Regulation Of DNA-templated Transcription In Response To Stress Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Protein Monoubiquitination Positive Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Cycle Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Negative Regulation Of Cell Cycle Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Cell Cycle Apoptotic Signaling Pathway Apoptotic Process Cellular Response To Oxygen Levels Positive Regulation Of Metabolic Process Cellular Response To Stimulus Programmed Cell Death Cellular Metabolic Process Cell Death Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Abiotic Stimulus Proteasomal Protein Catabolic Process Cell Cycle Arrest TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		aggressive ccrcc chemotherapeutic cytotoxic defective deficit define dramatically enhancer impairing impairs inactivated inactivation link mdm2 mechanistic modulator p53 rcc re regulators renders restoring stabilizes suppress treating tumours way wild	biologically bridges consistently cul degraded e3 etoposide hect ligase ligases list nedd4 proteasome rbx2 redox ring roc2 sag scf sensitizes shortened substrates terminus transcriptionally tri ubiquitin ubiquitylated ubiquitylates ubiquitylation
Tagcloud (Difference) ?		aggressive ccrcc chemotherapeutic cytotoxic defective deficit define dramatically enhancer impairing impairs inactivated inactivation link mdm2 mechanistic modulator p53 rcc re regulators renders restoring stabilizes suppress treating tumours way wild	biologically bridges consistently cul degraded e3 etoposide hect ligase ligases list nedd4 proteasome rbx2 redox ring roc2 sag scf sensitizes shortened substrates terminus transcriptionally tri ubiquitin ubiquitylated ubiquitylates ubiquitylation
Tagcloud (Intersection) ?