TRIM8 and BRAP

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		TRIM8	BRAP
Description		tripartite motif containing 8	BRCA1 associated protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Nuclear Body PML Body	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding Ubiquitin-protein Transferase Activity Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Canonical NF-kappaB Signal Transduction Positive Regulation Of Autophagy Protein Ubiquitination Stem Cell Population Maintenance Negative Regulation Of Viral Transcription Positive Regulation Of Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Protein K63-linked Ubiquitination Positive Regulation Of Protein Localization To Nucleus	MAPK Cascade Ras Protein Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination
Pathways		Interferon gamma signaling	RAF activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Feeling nervous ( 29500382) Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 23535732) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 26192919) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence ( 31591379) Alcohol dependence symptom count ( 29460428) Alcohol use disorder (consumption score) ( 30940813) Asthma ( 32296059 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Body mass index ( 25673413 26426971) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Coffee consumption ( 29367735) Colorectal cancer ( 26151821) Crohn's disease ( 28067908) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 21372407) Epilepsy ( 33913524) Esophageal cancer ( 19698717) Fish consumption ( 32895509) Gastroesophageal reflux disease ( 31527586) Hematological and biochemical traits ( 20139978) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908) LDL cholesterol ( 24097068 20686565) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 30226566) Parental lifespan ( 30642433) Platelet count ( 27863252) Plateletcrit ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25854761 28537254) Response to alcohol consumption (flushing response) ( 29460428) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum folate levels ( 29953918) Serum uric acid levels ( 29124443) Small vessel stroke (CCSp classification) ( 32047268) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 33080986) Tumor necrosis factor levels ( 32805626) Waist-to-hip ratio adjusted for BMI ( 34021172 34054925) Weight ( 34054925)
Interacting Genes		64 interacting genes: BRAP CATSPER1 CBL CCNH DCUN1D1 ESR1 FAM124B HOXA1 ITSN1 LNX1 LONRF1 MAGEC2 MKRN3 MSL2 MTURN NRIP1 NUDT10 OTUB2 PCGF5 RAD18 RAD23A RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF168 RNF181 RNF41 RNF7 SIAH1 SOCS1 TICAM1 TNFAIP3 TNPO2 TNS2 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UBXN7 UHRF2 USP2 USP21 USP39 USP5 USP7 XIAP YOD1	42 interacting genes: AKAP3 APOA1 ATMIN BRCA1 BRK1 CCDC30 CDC14A CENPF CNKSR1 DDB1 DNMT1 FAM184A FBXO2 HMG20A HRAS ISG15 KSR1 LINC00852 NUMA1 PHLPP1 RBM12 SHCBP1L SKP2 SMARCE1 SYNE2 TANC2 TEKTL1 TEX35 TRIM41 TRIM55 TRIM8 UBB UBC UBE2D2 UBE2H UBE2L3 USP15 USP4 YJU2 ZNF382 ZNF479 ZNF521
Entrez ID		81603	8315
HPRD ID		06934	05405
Ensembl ID		ENSG00000171206	ENSG00000089234
Uniprot IDs		Q9BZR9	Q59H81 Q7Z569
PDB IDs
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein Polyubiquitination Zinc Ion Binding Proteolysis Transferase Activity Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Autoubiquitination Metal Ion Binding Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Cysteine-type Deubiquitinase Activity Catabolic Process Protein Deubiquitination Protein Catabolic Process Nucleus Protein Modification By Small Protein Removal Proteasomal Protein Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Ubiquitin Binding Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination DNA Damage Response Nucleoplasm Protein K63-linked Ubiquitination Regulation Of Signal Transduction Cysteine-type Peptidase Activity Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination DNA Repair Cytoplasm Cytosol Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Protein K11-linked Deubiquitination Regulation Of Protein Stability Protein K11-linked Ubiquitination	Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Nucleus Regulation Of Post-translational Protein Modification Protein Polyubiquitination Protein Tag Activity Regulation Of Protein Ubiquitination Modification-dependent Protein Catabolic Process Dynein Complex Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Activity Regulation Of Cytokine-mediated Signaling Pathway Proteolysis Protein K48-linked Ubiquitination Ubiquitin-modified Histone Reader Activity Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Modification Process Regulation Of Signal Transduction Nucleoplasm Ubiquitin Protein Ligase Activity Regulation Of Cell Communication Regulation Of Signaling Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Organelle Organization Regulation Of Cell Cycle Phase Transition Microtubule-based Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling
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