TRIM8 and CCNH

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TRIM8	CCNH
Gene Name		tripartite motif containing 8	cyclin H
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol PML Body Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Holo TFIIH Complex Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex TFIIK Complex
	Molecular Function	Zinc Ion Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity	Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Viral Release From Host Cell	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Tat-mediated elongation of the HIV-1 transcript Cyclin E associated events during G1/S transition Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression G1/S Transition Mitotic G1-G1/S phases S Phase Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases Transcription of the HIV genome Nucleotide Excision Repair RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation HIV Infection RNA Polymerase I Promoter Clearance Formation of the Early Elongation Complex G2/M Transition RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Cyclin A/B1 associated events during G2/M transition RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER RNA Polymerase I Transcription mRNA Capping RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination G1 Phase Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic Cyclin D associated events in G1 Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Major depressive disorder ( 23377640)
Protein-Protein Interactions		45 interactors: BRAP CBL CCNH ITSN1 MAP3K7 MKRN3 MSL2 OTUB2 PCGF5 RAD18 RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF181 RNF41 RNF7 SIAH1 SOCS1 TNFAIP3 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UHRF2 USP2 USP21 USP39 USP7 XIAP	39 interactors: AR CALCOCO2 CCDC170 CCDC33 CCNC CDK2 CDK20 CDK7 CDK8 CSNK2B CTBP2 CTD DUSP12 ERCC3 ESR1 FUBP1 GANAB GOLGA2 GTF2E2 GTF2H1 KLC3 MBP MCM7 MNAT1 MTA1 MYC NDC80 NEDD4 POLR2A POLR2B PPFIA1 PSMA1 RARB SFN SSSCA1 SSX2IP SUPT5H TP53 TRIM8
Entrez ID		81603	902
HPRD ID		06934	09059
Ensembl ID		ENSG00000171206	ENSG00000134480
Uniprot IDs		Q9BZR9	P51946
PDB IDs			1JKW 1KXU
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Protein Deubiquitination Negative Regulation Of Type I Interferon Production Immune Response Toll-like Receptor Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Protein Modification By Small Protein Removal Regulation Of Metabolic Process Negative Regulation Of Viral Release From Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K48-linked Deubiquitination Regulation Of Gene Expression Protein K63-linked Deubiquitination Cellular Process Regulation Of Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine RNA Capping Regulation Of Viral Transcription DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription Viral Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Regulation Of Viral Process Nucleotide-excision Repair Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Stress Nucleotide-excision Repair, DNA Damage Removal Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cell Cycle Gene Expression Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Transcription Initiation From RNA Polymerase I Promoter Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase I Promoter DNA Repair Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Heterocycle Metabolic Process Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		aggressive ccrcc chemotherapeutic cytotoxic defective deficit define dramatically enhancer impairing impairs inactivated inactivation link mdm2 mechanistic modulator p53 rcc re regulators renders restoring stabilizes suppress treating tumours way wild	carrying chemotherapy conversely ercc5 ercc6 genotype genotypes genotyping good homozygous hrs longer median mms19l months os osteosarcoma pfs polymorphisms poor rflp rs1047768 rs17655 rs29001322 shorter tt undergoing xpc
Tagcloud (Difference) ?		aggressive ccrcc chemotherapeutic cytotoxic defective deficit define dramatically enhancer impairing impairs inactivated inactivation link mdm2 mechanistic modulator p53 rcc re regulators renders restoring stabilizes suppress treating tumours way wild	carrying chemotherapy conversely ercc5 ercc6 genotype genotypes genotyping good homozygous hrs longer median mms19l months os osteosarcoma pfs polymorphisms poor rflp rs1047768 rs17655 rs29001322 shorter tt undergoing xpc
Tagcloud (Intersection) ?