MLKL and S100A10

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MLKL	S100A10
Name		mixed lineage kinase domain like pseudokinase	S100 calcium binding protein A10
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cell Junction	Extracellular Region Cytoplasm Plasma Membrane Cell Surface Nuclear Matrix Extracellular Matrix Membrane Raft Extracellular Exosome RNA Polymerase II Transcription Regulator Complex Plasma Membrane Protein Complex AnxA2-p11 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding	Calcium Ion Binding Protein Binding Lipid Binding Protein Homodimerization Activity Transmembrane Transporter Binding Calcium-dependent Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Programmed Cell Death Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis	Membrane Raft Assembly Vesicle Budding From Membrane Positive Regulation Of Plasminogen Activation MRNA Transcription By RNA Polymerase II Positive Regulation Of GTPase Activity Positive Regulation Of Exocytosis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Protein Localization To Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Plasma Membrane Repair
Pathways		TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis	Dissolution of Fibrin Clot
Drugs		None	Phenethyl Isothiocyanate
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847 ) Testicular germ cell tumor ( 23666239 )	Asthma ( 31619474 ) Diverticular disease ( 30177863 ) Serum metabolite levels ( 33031748 ) Urinary metabolite levels in chronic kidney disease ( 29545352 ) Urinary metabolite ratios in chronic kidney disease ( 29545352 )
Interacting Genes		12 interacting genes: ANAPC11 CDK1 CEBPA CYLD ITCH NDUFB7 PSMB1 RAD18 S100A10 STAMBP THOC3 USP2	23 interacting genes: ANXA2 ANXA7 BAD CBR3 CDK16 COPS6 CTSB DSCAM ERBB3 FSHR KCNK3 MLKL NANOS2 PLA2G4C PLG S100A3 S100Z SETDB1 SUMO2 TRPV5 TRPV6 USP2 ZGPAT
Entrez ID		197259	6281
HPRD ID		08752	00232
Ensembl ID		ENSG00000168404	ENSG00000197747
Uniprot IDs		Q8NB16	P60903
PDB IDs		2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6LK5 6LK6 6O5Z 6UX8 6ZLE 6ZPR 6ZVO 6ZZ1 7JW7 7JXU 7MON 7NM2 7NM4 7NM5 8SLZ	1A4P 1BT6 4DRW 4FTG 4HRE 4HRG 4HRH
GO Terms Enriched among Interactors		Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Macromolecule Metabolic Process Protein Modification Process Nucleoplasm Regulation Of Cell Cycle K63-linked Deubiquitinase Activity Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Proteolysis Protein K63-linked Deubiquitination Positive Regulation Of Chromosome Segregation Regulation Of Necroptotic Process Cyclin Binding Negative Regulation Of JNK Cascade Regulation Of Programmed Necrotic Cell Death Protein Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Type I Interferon Production Pronuclear Fusion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Rad6-Rad18 Complex Protein Monoubiquitination Positive Regulation Of Cell Cycle Process Centrosome Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Vitamin B2 C/EBP Complex Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process AnxA2-p11 Complex Protein Autoubiquitination Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity CHOP-C/EBP Complex Protein Linear Deubiquitination Cysteine-type Deubiquitinase Activity Hippocampal Neuron Apoptotic Process Ubiquitin Protein Ligase Activity	Calcium-dependent Protein Binding Calcium-dependent Phospholipid Binding Plasma Membrane S100 Protein Binding