MLKL and NDUFB7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MLKL	NDUFB7
Description		mixed lineage kinase domain like pseudokinase	NADH:ubiquinone oxidoreductase subunit B7
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cell Junction	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Respiratory Chain Complex I
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Programmed Cell Death Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways		TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Testicular germ cell tumor ( 23666239)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		12 interacting genes: ANAPC11 CDK1 CEBPA CYLD ITCH NDUFB7 PSMB1 RAD18 S100A10 STAMBP THOC3 USP2	42 interacting genes: AGBL2 AIRIM ANKRD36B ATG9A CAPN1 CCDC24 CCNC CDCA7L CDKN2D CHIC2 CINP CKAP4 CTNNA3 DSCR9 ENKD1 FAM161B FAM90A1 GEM GPATCH2L GYS1 KRTAP10-10 LMO2 MAGOHB MAK MEIS2 MKRN3 MLKL NDUFB2 NFKBIB NFKBID RCOR3 RECK RIPPLY1 RIPPLY2 SCNM1 SPRED2 STRA6 TLE5 ZNF330 ZNF417 ZNF564 ZNF587
Entrez ID		197259	4713
HPRD ID		08752	11957
Ensembl ID		ENSG00000168404	ENSG00000099795
Uniprot IDs		Q8NB16	P17568
PDB IDs		2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6LK5 6LK6 6O5Z 6UX8 6ZLE 6ZPR 6ZVO 6ZZ1 7JW7 7JXU 7MON 7NM2 7NM4 7NM5 8SLZ	5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Macromolecule Metabolic Process Protein Modification Process Nucleoplasm Regulation Of Cell Cycle K63-linked Deubiquitinase Activity Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Proteolysis Protein K63-linked Deubiquitination Positive Regulation Of Chromosome Segregation Regulation Of Necroptotic Process Cyclin Binding Negative Regulation Of JNK Cascade Regulation Of Programmed Necrotic Cell Death Protein Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Type I Interferon Production Pronuclear Fusion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Rad6-Rad18 Complex Protein Monoubiquitination Positive Regulation Of Cell Cycle Process Centrosome Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Vitamin B2 C/EBP Complex Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process AnxA2-p11 Complex Protein Autoubiquitination Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity CHOP-C/EBP Complex Protein Linear Deubiquitination Cysteine-type Deubiquitinase Activity Hippocampal Neuron Apoptotic Process Ubiquitin Protein Ligase Activity
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