MLKL and ITCH

Number of citations of the paper that reports this interaction (PubMedID 34999730)
66

Data Source:
BioGRID (pull down, enzymatic study)

		MLKL	ITCH
Description		mixed lineage kinase domain like pseudokinase	itchy E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cell Junction	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endosome Early Endosome Cytosol Plasma Membrane Cell Cortex Endosome Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Extracellular Exosome Cell Periphery
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ribonucleoprotein Complex Binding Ubiquitin-like Protein Ligase Binding CXCR Chemokine Receptor Binding Ubiquitin Protein Ligase Activity Arrestin Family Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Programmed Cell Death Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis	Protein Polyubiquitination Regulation Of Cell Growth Immune System Process Positive Regulation Of T Cell Anergy Negative Regulation Of Immune System Process Positive Regulation Of Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway T Cell Anergy Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Inflammatory Response Response To Oxidative Stress Positive Regulation Of Catabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Protein Catabolic Process Receptor Internalization Negative Regulation Of Type I Interferon Production Protein K29-linked Ubiquitination CD4-positive, Alpha-beta T Cell Proliferation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Symbiont Entry Into Host Cell Negative Regulation Of Defense Response To Virus Negative Regulation Of Multicellular Organismal Process Defense Response To Virus Protein Autoubiquitination Regulation Of Necroptotic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Protein Deubiquitination Protein Branched Polyubiquitination Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Receptor Catabolic Process
Pathways		TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis	Downregulation of ERBB4 signaling NOD1/2 Signaling Pathway Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Degradation of GLI1 by the proteasome Hedgehog 'on' state Regulation of necroptotic cell death RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Testicular germ cell tumor ( 23666239)	Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31015462 31152163) Fish- and plant-related diet ( 32066663) Heel bone mineral density ( 28869591) Hip circumference adjusted for BMI ( 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Vitiligo ( 27723757)
Interacting Genes		12 interacting genes: ANAPC11 CDK1 CEBPA CYLD ITCH NDUFB7 PSMB1 RAD18 S100A10 STAMBP THOC3 USP2	132 interacting genes: AGO2 AKT1 ARHGEF7 ARID1A ARRB2 ARRDC3 ATN1 BECN1 BIN1 BRAF CBL CBLC CDC34 CPSF6 CPSF7 CSNK2A1 CXCR4 CYLD DAZAP1 DSCR9 DTX1 DTX3L ERBB4 ESS2 EWSR1 FYN GJA1 GLIS3 GNAI2 H1-2 HNRNPUL1 JUN JUNB KIAA1210 KPNB1 KSR1 LAPTM5 LITAF LRRK1 MAP2 MAP2K1 MAP2K4 MAP3K2 MAPK8 MLANA MLKL MYCT1 N4BP1 NDFIP1 NDFIP2 NEDD9 NFE2 NOTCH1 NRAS NUDT21 NUMB PABPC1 PACSIN1 PIP4P2 POLR2A POLR2B POLR2C POLR2E POU5F1 PRKACA PRRG4 RAF1 RBM14 REPS2 RHBDD1 RIPK1 RNF11 RORA RPAP2 RPAP3 SCNN1A SCNN1B SF1 SGK3 SH3GL1 SH3GL2 SIK1 SMAD2 SMAD3 SMARCC1 SMARCC2 SMARCE1 SMN1 SNX9 SPART SPEN STAM2 STRIP2 SUFU TAB1 TAF15 TGFB1I1 TMEM51 TP73 TRERF1 TRPC4 TRPV1 TRPV4 TTYH3 UBAP2 UBAP2L UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2O UBE2Q1 UBE2Q2 UBE2R2 URI1 UVRAG WASL WBP2 YWHAQ YY1 ZC3H14
Entrez ID		197259	83737
HPRD ID		08752	07565
Ensembl ID		ENSG00000168404	ENSG00000078747
Uniprot IDs		Q8NB16	Q96J02
PDB IDs		2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6LK5 6LK6 6O5Z 6UX8 6ZLE 6ZPR 6ZVO 6ZZ1 7JW7 7JXU 7MON 7NM2 7NM4 7NM5 8SLZ	2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG 4ROF 5C7M 5CQ2 5DWS 5DZD 5SXP
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Macromolecule Metabolic Process Protein Modification Process Nucleoplasm Regulation Of Cell Cycle K63-linked Deubiquitinase Activity Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Proteolysis Protein K63-linked Deubiquitination Positive Regulation Of Chromosome Segregation Regulation Of Necroptotic Process Cyclin Binding Negative Regulation Of JNK Cascade Regulation Of Programmed Necrotic Cell Death Protein Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Type I Interferon Production Pronuclear Fusion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Rad6-Rad18 Complex Protein Monoubiquitination Positive Regulation Of Cell Cycle Process Centrosome Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Vitamin B2 C/EBP Complex Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process AnxA2-p11 Complex Protein Autoubiquitination Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity CHOP-C/EBP Complex Protein Linear Deubiquitination Cysteine-type Deubiquitinase Activity Hippocampal Neuron Apoptotic Process Ubiquitin Protein Ligase Activity	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Nucleus Cytosol Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Nucleotide Binding WW Domain Binding Regulation Of Primary Metabolic Process Protein Binding Intracellular Signal Transduction Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Modification Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Cytoplasm Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Ubiquitination Negative Regulation Of Metabolic Process
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