MLKL and THOC3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MLKL	THOC3
Description		mixed lineage kinase domain like pseudokinase	THO complex subunit 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cell Junction	Transcription Export Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding	RNA Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Programmed Cell Death Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis	MRNA Processing MRNA Export From Nucleus RNA Splicing MRNA Transport
Pathways		TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Testicular germ cell tumor ( 23666239)	Chronotype ( 30696823)
Interacting Genes		12 interacting genes: ANAPC11 CDK1 CEBPA CYLD ITCH NDUFB7 PSMB1 RAD18 S100A10 STAMBP THOC3 USP2	7 interacting genes: BRCA1 DDX39B DLG4 MLKL PFKFB4 PTEN TK1
Entrez ID		197259	84321
HPRD ID		08752	09497
Ensembl ID		ENSG00000168404	ENSG00000051596
Uniprot IDs		Q8NB16	Q96J01
PDB IDs		2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6LK5 6LK6 6O5Z 6UX8 6ZLE 6ZPR 6ZVO 6ZZ1 7JW7 7JXU 7MON 7NM2 7NM4 7NM5 8SLZ	7APK 7ZNK 7ZNL
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Macromolecule Metabolic Process Protein Modification Process Nucleoplasm Regulation Of Cell Cycle K63-linked Deubiquitinase Activity Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Proteolysis Protein K63-linked Deubiquitination Positive Regulation Of Chromosome Segregation Regulation Of Necroptotic Process Cyclin Binding Negative Regulation Of JNK Cascade Regulation Of Programmed Necrotic Cell Death Protein Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Type I Interferon Production Pronuclear Fusion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Rad6-Rad18 Complex Protein Monoubiquitination Positive Regulation Of Cell Cycle Process Centrosome Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Vitamin B2 C/EBP Complex Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process AnxA2-p11 Complex Protein Autoubiquitination Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity CHOP-C/EBP Complex Protein Linear Deubiquitination Cysteine-type Deubiquitinase Activity Hippocampal Neuron Apoptotic Process Ubiquitin Protein Ligase Activity	Dendritic Spine Morphogenesis Identical Protein Binding Positive Regulation Of Excitatory Postsynaptic Potential Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Social Behavior Dendritic Spine Organization Postsynapse Organization P2Y1 Nucleotide Receptor Binding Negative Regulation Of Synaptic Vesicle Clustering Small Molecule Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Protein-containing Complex Assembly PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Thymidine Kinase Activity Cellular Component Assembly Beta-1 Adrenergic Receptor Binding Regulation Of Nervous System Process Regulation Of Grooming Behavior ATP Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission DNA Synthesis Involved In Mitotic DNA Replication Execution Phase Of Necroptosis Protein-containing Complex Organization BRCA1-B Complex Cellular Response To Indole-3-methanol Negative Regulation Of Mitotic Cell Cycle Phase Transition AMPA Glutamate Receptor Clustering Dendritic Spine Neuroligin Family Protein Binding Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Thymidine Biosynthetic Process Negative Regulation Of Centriole Replication Negative Regulation Of Cellular Component Organization Nuclear Ubiquitin Ligase Complex BRCA1-C Complex
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