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PSMA3 and STX6
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
PSMA3
STX6
Description
proteasome 20S subunit alpha 3
syntaxin 6
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Exosome
Golgi Membrane
Nucleoplasm
Endosome
Early Endosome
Golgi Apparatus
Trans-Golgi Network
Cytosol
Plasma Membrane
Endomembrane System
Membrane
Clathrin-coated Vesicle
Synaptic Vesicle Membrane
Organelle Membrane
SNARE Complex
Vesicle
Trans-Golgi Network Membrane
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Recycling Endosome
Recycling Endosome Membrane
Molecular Function
Protein Binding
Ubiquitin Protein Ligase Binding
SNARE Binding
SNAP Receptor Activity
Protein Binding
Syntaxin Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Intracellular Protein Transport
Vesicle Fusion
Endosome Organization
Protein Transport
Synaptic Vesicle To Endosome Fusion
Vesicle-mediated Transport
Endocytic Recycling
Regulation Of Protein Localization
Retrograde Transport, Endosome To Golgi
Golgi Vesicle Transport
Vesicle Docking
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
Antigen processing: Ub, ATP-independent proteasomal degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Phenethyl Isothiocyanate
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Creutzfeldt-Jakob disease (sporadic) (
32949544
)
Intralaminar thalamic nuclei volume (
34006833
)
Menopause (age at onset) (
26414677
)
Progressive supranuclear palsy (
21685912
30089514
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
120 interacting genes:
ADGRL1
APLN
ATN1
ATP6V0C
AURKB
BTN2A2
BTRC
C1orf105
CCDC69
CCL28
CDK6
CDKN1A
CEBPA
CIP2A
CRB3
CRYAB
CSNK2A1
CST2
CTBP1-DT
CYBA
DDX5
DGLUCY
DMC1
DMRT3
DVL1
EGR1
FAM171A2
FAM218A
FAM83A
FBXL18
FNDC3B
FOS
FRAT1
GATA2
GATA3
GFI1B
GORASP2
HHEX
HSPB1
IKBKG
ILF3
IQCE
KIF1A
KIRREL2
KIRREL3-AS3
KRAS
KRTAP19-5
KRTAP26-1
KRTAP8-1
LASP1
LBP
LETM1
LINC00908
LINC02913
MDM2
MIA2
NEU4
NOL4L-DT
NPBWR2
NPPB
NUMBL
OLIG2
OSR2
PATL1
PCOTH
PLK1
PML
POMP
PRELID3A
PRNP
PRR13
PRR3
PRRC2A
PSMA1
PSMA2
PSMA4
PSMA6
PSMA7
PSMB10
PSMB5
PTPN23
PWWP2B
PWWP3A
RAB3IL1
RAD54L2
RAMAC
RBFOX2
RERE
RFT1
RTP5
RUSC1-AS1
SERF2
SF1
SH3KBP1
SLAIN1
SLC22A23
SNRPB
SNRPC
SNRPF
SPATA8
SRPK2
STUB1
STX11
STX1A
STX4
STX6
TBC1D16
TBX6
TCF7L2
TINCR
TP53
TRIB3
UBD
URB1-AS1
VPS37C
XRN2
YPEL3
ZNF366
ZNF385C
ZNF688
33 interacting genes:
AQP6
ARMC8
DNAJC5
EBP
EEA1
FAM210B
GOLM2
GOPC
LIME1
LMNA
MARCHF2
MEOX2
MMGT1
MTERF2
MTIF3
NAPB
PSMA3
PTPN9
SCN3B
SNAP23
SNAP29
STOM
STX16
STX1A
STX2
STX7
TIMMDC1
TMEM14B
TMEM205
TMEM86B
VAMP4
VPS11
VPS18
Entrez ID
5684
10228
HPRD ID
01463
07231
Ensembl ID
ENSG00000100567
ENSG00000135823
Uniprot IDs
A0A140VK43
P25788
O43752
PDB IDs
4R3O
4R67
5A0Q
5DSV
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
7AWE
7B12
7E55
7LXV
7NAN
7NAO
7NAP
7NAQ
7NHT
7PG9
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7V5G
7V5M
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8BZL
8CVR
8CVS
8CVT
8CXB
8JRI
8JRT
8JTI
8K0G
8QYJ
8QYL
8QYM
8QYN
8QYO
8QYS
8QZ9
8TM3
8TM4
8TM5
8TM6
8UD9
8USB
8USC
8YIX
8YIY
8YIZ
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
9HMN
2NPS
4J2C
Enriched GO Terms of Interacting Partners
?
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Response To Gamma Radiation
Proteasome Complex
Cellular Response To Gamma Radiation
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of MiRNA Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of MiRNA Metabolic Process
Response To Ionizing Radiation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin-dependent Protein Catabolic Process
Protein Binding
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Response To Gravity
Cellular Response To Ionizing Radiation
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Molecular Function Activator Activity
Macromolecule Catabolic Process
Negative Regulation Of Cell Cycle
Nuclear Matrix
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Protein Destabilization
Regulation Of Protein Stability
HMG Box Domain Binding
Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteolysis
Regulation Of Hormone Metabolic Process
Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
SNAP Receptor Activity
Proteasomal Protein Catabolic Process
Cellular Response To Actinomycin D
Promoter-specific Chromatin Binding
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Cellular Senescence
Organelle Fusion
Vesicle Fusion
Organelle Membrane Fusion
SNARE Complex
Syntaxin Binding
Membrane Fusion
SNAP Receptor Activity
Organelle Localization By Membrane Tethering
Vesicle Organization
Membrane Docking
Vesicle Docking
Vesicle-mediated Transport
Membrane Organization
Cytoplasmic Vesicle
Establishment Of Protein Localization
Protein Transport
Intracellular Protein Transport
Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Vesicle Fusion To Plasma Membrane
Organelle Localization
Cellular Localization
Establishment Of Localization In Cell
Synaptic Vesicle Membrane Organization
Membrane
SNARE Binding
Intracellular Transport
Synaptic Vesicle To Endosome Fusion
Intracellular Protein Localization
Endosome Organization
Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
Exocytosis
Localization Within Membrane
Vesicle Docking Involved In Exocytosis
Lysosomal Membrane
ATP-dependent Protein Binding
Chloride Channel Inhibitor Activity
CORVET Complex
Azurophil Granule Membrane
Endomembrane System
Regulation Of Synaptic Vesicle Priming
Azurophil Granule
SNARE Complex Assembly
Regulation Of Protein Localization
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
HOPS Complex
Endocytic Vesicle
Early Endosome
Regulation Of SNARE Complex Assembly
Endosomal Vesicle Fusion
Vesicle Targeting
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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