Wiki-Pi
About
Search
People
Updates
Search
PSMA3 and STX4
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
PSMA3
STX4
Description
proteasome 20S subunit alpha 3
syntaxin 4
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Exosome
Storage Vacuole
Extracellular Space
Cytoplasm
Endosome
Vacuole
Trans-Golgi Network
Cytosol
Plasma Membrane
Cell Surface
Endomembrane System
Membrane
Basolateral Plasma Membrane
Lamellipodium
Phagocytic Vesicle Membrane
SNARE Complex
Stereocilium
Neuron Projection Membrane
Myelin Sheath Adaxonal Region
Somatodendritic Compartment
Specific Granule
Cell Projection
Neuron Projection
Dendritic Spine
Lateral Loop
Synapse
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Postsynapse
Glutamatergic Synapse
Molecular Function
Protein Binding
Ubiquitin Protein Ligase Binding
SNARE Binding
SNAP Receptor Activity
Protein Binding
Sphingomyelin Phosphodiesterase Activator Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of Immunoglobulin Production
Neurotransmitter Transport
Intracellular Protein Transport
Exocytosis
Vesicle Fusion
Sensory Perception Of Sound
Positive Regulation Of Cell Population Proliferation
Vesicle-mediated Transport
Regulation Of Exocytosis
Positive Regulation Of Cell Migration
Protein Localization To Cell Surface
Cellular Response To Oxidative Stress
SNARE Complex Assembly
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Catalytic Activity
Positive Regulation Of Eosinophil Degranulation
Positive Regulation Of Cell Adhesion
Vesicle Docking
Organelle Fusion
Positive Regulation Of Chemotaxis
Long-term Synaptic Potentiation
Membrane Organization
Cellular Response To Type II Interferon
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Protein Localization To Plasma Membrane
Cornified Envelope Assembly
Positive Regulation Of Protein Localization To Cell Surface
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
Antigen processing: Ub, ATP-independent proteasomal degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Disinhibition of SNARE formation
ER-Phagosome pathway
Translocation of SLC2A4 (GLUT4) to the plasma membrane
trans-Golgi Network Vesicle Budding
Other interleukin signaling
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Phenethyl Isothiocyanate
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Response to metformin (IC50) (
28173075
)
Triglyceride levels (
32203549
)
Interacting Genes
120 interacting genes:
ADGRL1
APLN
ATN1
ATP6V0C
AURKB
BTN2A2
BTRC
C1orf105
CCDC69
CCL28
CDK6
CDKN1A
CEBPA
CIP2A
CRB3
CRYAB
CSNK2A1
CST2
CTBP1-DT
CYBA
DDX5
DGLUCY
DMC1
DMRT3
DVL1
EGR1
FAM171A2
FAM218A
FAM83A
FBXL18
FNDC3B
FOS
FRAT1
GATA2
GATA3
GFI1B
GORASP2
HHEX
HSPB1
IKBKG
ILF3
IQCE
KIF1A
KIRREL2
KIRREL3-AS3
KRAS
KRTAP19-5
KRTAP26-1
KRTAP8-1
LASP1
LBP
LETM1
LINC00908
LINC02913
MDM2
MIA2
NEU4
NOL4L-DT
NPBWR2
NPPB
NUMBL
OLIG2
OSR2
PATL1
PCOTH
PLK1
PML
POMP
PRELID3A
PRNP
PRR13
PRR3
PRRC2A
PSMA1
PSMA2
PSMA4
PSMA6
PSMA7
PSMB10
PSMB5
PTPN23
PWWP2B
PWWP3A
RAB3IL1
RAD54L2
RAMAC
RBFOX2
RERE
RFT1
RTP5
RUSC1-AS1
SERF2
SF1
SH3KBP1
SLAIN1
SLC22A23
SNRPB
SNRPC
SNRPF
SPATA8
SRPK2
STUB1
STX11
STX1A
STX4
STX6
TBC1D16
TBX6
TCF7L2
TINCR
TP53
TRIB3
UBD
URB1-AS1
VPS37C
XRN2
YPEL3
ZNF366
ZNF385C
ZNF688
65 interacting genes:
ABI2
ACTB
ANKRD46
BET1
CYBRD1
DLG1
DNAJC5
FAXDC2
GIMAP5
GOSR2
GPR152
ITSN2
LLGL1
LMNA
NAPA
NAPB
NSF
PLP1
PSMA3
RAB11A
RAB4A
RAB5A
RNF4
SCRIB
SEC22A
SEC22B
SEPTIN5
SERP1
SGPL1
SH3GLB2
SNAP23
SNAP25
SNAP47
STX10
STX11
STX16
STX1A
STX1B
STX2
STX3
STX5
STXBP3
STXBP4
STXBP5
STXBP6
SYT1
SYT4
SYT7
TCEANC
TMEM203
TRAF3IP3
TXLNA
TXLNB
TXLNG
USE1
VAMP1
VAMP2
VAMP3
VAMP4
VAMP7
VAMP8
VAPB
VMA12
VTI1B
ZFPL1
Entrez ID
5684
6810
HPRD ID
01463
01722
Ensembl ID
ENSG00000100567
ENSG00000103496
Uniprot IDs
A0A140VK43
P25788
B7Z425
Q12846
PDB IDs
4R3O
4R67
5A0Q
5DSV
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
7AWE
7B12
7E55
7LXV
7NAN
7NAO
7NAP
7NAQ
7NHT
7PG9
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7V5G
7V5M
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8BZL
8CVR
8CVS
8CVT
8CXB
8JRI
8JRT
8JTI
8K0G
8QYJ
8QYL
8QYM
8QYN
8QYO
8QYS
8QZ9
8TM3
8TM4
8TM5
8TM6
8UD9
8USB
8USC
8YIX
8YIY
8YIZ
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
9HMN
Enriched GO Terms of Interacting Partners
?
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Response To Gamma Radiation
Proteasome Complex
Cellular Response To Gamma Radiation
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of MiRNA Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of MiRNA Metabolic Process
Response To Ionizing Radiation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin-dependent Protein Catabolic Process
Protein Binding
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Response To Gravity
Cellular Response To Ionizing Radiation
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Molecular Function Activator Activity
Macromolecule Catabolic Process
Negative Regulation Of Cell Cycle
Nuclear Matrix
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Protein Destabilization
Regulation Of Protein Stability
HMG Box Domain Binding
Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteolysis
Regulation Of Hormone Metabolic Process
Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
SNAP Receptor Activity
Proteasomal Protein Catabolic Process
Cellular Response To Actinomycin D
Promoter-specific Chromatin Binding
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Cellular Senescence
SNAP Receptor Activity
SNARE Complex
Membrane Fusion
Syntaxin Binding
Vesicle Fusion
Organelle Membrane Fusion
Organelle Fusion
Vesicle-mediated Transport
Membrane Organization
SNARE Binding
Vesicle Organization
Exocytosis
Organelle Localization By Membrane Tethering
Establishment Of Localization In Cell
Membrane Docking
Secretion By Cell
Vesicle Docking
Protein Transport
Secretion
Establishment Of Protein Localization
Vesicle-mediated Transport In Synapse
Golgi Vesicle Transport
Cellular Localization
Intracellular Protein Localization
Intracellular Transport
Organelle Localization
Regulation Of Vesicle-mediated Transport
Endomembrane System
Calcium-ion Regulated Exocytosis
SNARE Complex Assembly
Membrane
Regulated Exocytosis
Regulation Of Exocytosis
Syntaxin-1 Binding
Synaptic Vesicle Exocytosis
Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Intracellular Protein Transport
Vesicle Fusion To Plasma Membrane
Regulation Of Secretion By Cell
Synaptic Vesicle Membrane
Regulation Of Secretion
Synaptic Vesicle Membrane Organization
Signal Release
Regulation Of Transport
Regulation Of Regulated Secretory Pathway
Synaptic Vesicle
Calcium Ion-regulated Exocytosis Of Neurotransmitter
Vesicle Docking Involved In Exocytosis
Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
Post-Golgi Vesicle-mediated Transport
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?