PSMA3 and STUB1

Number of citations of the paper that reports this interaction (PMID 11146632)
214

Data Source:
HPRD (in vivo)

		PSMA3	STUB1
Gene Name		proteasome (prosome, macropain) subunit, alpha type, 3	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Threonine-type Endopeptidase Activity Protein Binding	G-protein Coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein Binding, Bridging TPR Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Misfolded Or Incompletely Synthesized Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by ERBB2 Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		114 interactors: APLN ATN1 ATP6V0C AURKB BTN2A2 BTRC C14orf159 C1orf105 C1QTNF9B-AS1 C9orf106 CCDC69 CCL28 CDK6 CDKN1A CRB3 CRYAB CSNK2A1 CST2 CTAGE5 CTBP1-AS2 CYBA DDX5 DMC1 DMRT3 DVL1 EGR1 FAM103A1 FAM171A2 FAM218A FBXL18 FBXO7 FRAT1 GATA2 GATA3 GFI1B GORASP2 HHEX HNRNPA2B1 IKBKG IQCE KIF1A KIRREL2 KIRREL3-AS3 KRAS KRTAP19-5 KRTAP26-1 KRTAP8-1 LASP1 LBP LETM1 LINC00908 LOC149950 LPHN1 MDM2 MUM1 NEU4 NPBWR2 NPPB NUMBL OSR2 PATL1 PLK1 PML POMP PRNP PRR13 PRR3 PRRC2A PSMA1 PSMA2 PSMA4 PSMA6 PSMA7 PSMB10 PSMB4 PSMB5 PSMD1 PTPN23 PWWP2B RAB3IL1 RAD54L2 RBFOX2 RBM42 RERE RFT1 RTP5 RUSC1-AS1 SERF2 SF1 SH3KBP1 SLAIN1 SLC22A23 SLMO1 SNRPB SNRPC SNRPF SPATA8 SRPK2 STUB1 STX11 STX1A STX4 STX6 TBC1D16 TBX6 TCF7L2 TINCR TRIB3 URB1-AS1 VPS37C XRN2 YPEL3 ZNF366 ZNF385C	92 interactors: ABL1 ACD AHR AR ATCAY ATXN3 BAG1 BAG5 BCR BMPR1B CCL28 CTBP2 CYP2E1 CYP3A4 DAXX DNAJB1 DYX1C1 EIF5A ERBB2 ERN1 ESR1 FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A2 GUCY1A3 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 IRF1 JOSD1 JOSD2 KHDRBS1 KIAA1524 MAP3K11 MAP3K2 MAPT MCF2 MITF MPP1 MST1R MYOCD NOS1 NQO1 OLFM3 PARK2 PFN1 POLB POT1 PRKCZ PSMA3 PSMD4 RAF1 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SRC TAL1 TERF1 TGFBR1 TINF2 TRAF6 TXN2 UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2W VCP XIAP
Entrez ID		5684	10273
HPRD ID		01463	06232
Ensembl ID		ENSG00000100567	ENSG00000103266
Uniprot IDs		P25788	Q9UNE7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic Cell Cycle Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Integrity Checkpoint Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Negative Regulation Of Transferase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Damage Checkpoint Regulation Of Wnt Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Proteolysis Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Cellular Response To Stimulus Protein Polyubiquitination Response To Stress Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Response To Stimulus Cellular Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Gene Expression Cellular Response To Stress Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cell Death Protein Ubiquitination Response To Growth Factor Regulation Of Cellular Component Organization Protein Modification By Small Protein Conjugation Cellular Protein Metabolic Process Regulation Of Cellular Process Cell Communication Positive Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Regulation Of Apoptotic Process Regulation Of Immune System Process Signaling Cell Death Death Cellular Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Negative Regulation Of Protein Metabolic Process Protein Metabolic Process
Tagcloud ?		20s alpha5 alpha6 alpha7 alphal apparatus cations dephosphorylation electrophoretic endonuclease endoribonuclease hydrolysates possession postranslational proteasomal proteasome proteasomes proteolysis psma1 psma5 psma6 ptm ribonucleoprotein rnase scarcely spectrometric tryptic utr varies	atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike
Tagcloud (Difference) ?		20s alpha5 alpha6 alpha7 alphal apparatus cations dephosphorylation electrophoretic endonuclease endoribonuclease hydrolysates possession postranslational proteasomal proteasome proteasomes proteolysis psma1 psma5 psma6 ptm ribonucleoprotein rnase scarcely spectrometric tryptic utr varies	atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike
Tagcloud (Intersection) ?